Pharmacological inhibition of CXCR2 chemokine receptors modulates paraquat-induced intoxication in rats.

Paraquat (PQ) is an agrochemical agent commonly used worldwide, which is allied to potential risks of intoxication. This herbicide induces the formation of reactive oxygen species (ROS) that ends up compromising various organs, particularly the lungs and the brain. This study evaluated the deleterio...

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Autores principales:	Kesiane M Costa, Izaque S Maciel, Luiza W Kist, Maria M Campos, Maurício R Bogo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa670e1cef764646bb8e904120810eb6
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spelling	oai:doaj.org-article:aa670e1cef764646bb8e904120810eb62021-11-25T06:03:26ZPharmacological inhibition of CXCR2 chemokine receptors modulates paraquat-induced intoxication in rats.1932-620310.1371/journal.pone.0105740https://doaj.org/article/aa670e1cef764646bb8e904120810eb62014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25153082/?tool=EBIhttps://doaj.org/toc/1932-6203Paraquat (PQ) is an agrochemical agent commonly used worldwide, which is allied to potential risks of intoxication. This herbicide induces the formation of reactive oxygen species (ROS) that ends up compromising various organs, particularly the lungs and the brain. This study evaluated the deleterious effects of paraquat on the central nervous system (CNS) and peripherally, with special attempts to assess the putative protective effects of the selective CXCR2 receptor antagonist SB225002 on these parameters. PQ-toxicity was induced in male Wistar rats, in a total dose of 50 mg/kg, and control animals received saline solution at the same schedule of administration. Separate groups of animals were treated with the selective CXCR2 antagonist SB225002 (1 or 3 mg/kg), administered 30 min before each paraquat injection. The major changes found in paraquat-treated animals were: decreased body weight and hypothermia, nociception behavior, impairment of locomotor and gait capabilities, enhanced TNF-α and IL-1β expression in the striatum, and cell migration to the lungs and blood. Some of these parameters were reversed when the antagonist SB225002 was administered, including recovery of physiological parameters, decreased nociception, improvement of gait abnormalities, modulation of striatal TNF-α and IL-1β expression, and decrease of neutrophil migration to the lungs and blood. Taken together, our results demonstrate that damage to the central and peripheral systems elicited by paraquat can be prevented by the pharmacological inhibition of CXCR2 chemokine receptors. The experimental evidence presented herein extends the comprehension on the toxicodynamic aspects of paraquat, and opens new avenues to treat intoxication induced by this herbicide.Kesiane M CostaIzaque S MacielLuiza W KistMaria M CamposMaurício R BogoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105740 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kesiane M Costa Izaque S Maciel Luiza W Kist Maria M Campos Maurício R Bogo Pharmacological inhibition of CXCR2 chemokine receptors modulates paraquat-induced intoxication in rats.
description	Paraquat (PQ) is an agrochemical agent commonly used worldwide, which is allied to potential risks of intoxication. This herbicide induces the formation of reactive oxygen species (ROS) that ends up compromising various organs, particularly the lungs and the brain. This study evaluated the deleterious effects of paraquat on the central nervous system (CNS) and peripherally, with special attempts to assess the putative protective effects of the selective CXCR2 receptor antagonist SB225002 on these parameters. PQ-toxicity was induced in male Wistar rats, in a total dose of 50 mg/kg, and control animals received saline solution at the same schedule of administration. Separate groups of animals were treated with the selective CXCR2 antagonist SB225002 (1 or 3 mg/kg), administered 30 min before each paraquat injection. The major changes found in paraquat-treated animals were: decreased body weight and hypothermia, nociception behavior, impairment of locomotor and gait capabilities, enhanced TNF-α and IL-1β expression in the striatum, and cell migration to the lungs and blood. Some of these parameters were reversed when the antagonist SB225002 was administered, including recovery of physiological parameters, decreased nociception, improvement of gait abnormalities, modulation of striatal TNF-α and IL-1β expression, and decrease of neutrophil migration to the lungs and blood. Taken together, our results demonstrate that damage to the central and peripheral systems elicited by paraquat can be prevented by the pharmacological inhibition of CXCR2 chemokine receptors. The experimental evidence presented herein extends the comprehension on the toxicodynamic aspects of paraquat, and opens new avenues to treat intoxication induced by this herbicide.
format	article
author	Kesiane M Costa Izaque S Maciel Luiza W Kist Maria M Campos Maurício R Bogo
author_facet	Kesiane M Costa Izaque S Maciel Luiza W Kist Maria M Campos Maurício R Bogo
author_sort	Kesiane M Costa
title	Pharmacological inhibition of CXCR2 chemokine receptors modulates paraquat-induced intoxication in rats.
title_short	Pharmacological inhibition of CXCR2 chemokine receptors modulates paraquat-induced intoxication in rats.
title_full	Pharmacological inhibition of CXCR2 chemokine receptors modulates paraquat-induced intoxication in rats.
title_fullStr	Pharmacological inhibition of CXCR2 chemokine receptors modulates paraquat-induced intoxication in rats.
title_full_unstemmed	Pharmacological inhibition of CXCR2 chemokine receptors modulates paraquat-induced intoxication in rats.
title_sort	pharmacological inhibition of cxcr2 chemokine receptors modulates paraquat-induced intoxication in rats.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/aa670e1cef764646bb8e904120810eb6
work_keys_str_mv	AT kesianemcosta pharmacologicalinhibitionofcxcr2chemokinereceptorsmodulatesparaquatinducedintoxicationinrats AT izaquesmaciel pharmacologicalinhibitionofcxcr2chemokinereceptorsmodulatesparaquatinducedintoxicationinrats AT luizawkist pharmacologicalinhibitionofcxcr2chemokinereceptorsmodulatesparaquatinducedintoxicationinrats AT mariamcampos pharmacologicalinhibitionofcxcr2chemokinereceptorsmodulatesparaquatinducedintoxicationinrats AT mauriciorbogo pharmacologicalinhibitionofcxcr2chemokinereceptorsmodulatesparaquatinducedintoxicationinrats
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Pharmacological inhibition of CXCR2 chemokine receptors modulates paraquat-induced intoxication in rats.

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