ROCKII inhibition promotes the maturation of human pancreatic beta-like cells

ROCKII inhibition promotes the maturation of human pancreatic beta-like cells

Our incomplete understanding of how pancreatic beta cells form limits the generation of beta-like cells from human pluripotent stem cells (hPSC). Here, the authors identify a ROCKII inhibitor H1152 as increasing insulin secreting cells from hPSCs and improving beta-cell maturation on transplantation...

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Autores principales: Zaniar Ghazizadeh, Der-I Kao, Sadaf Amin, Brandoch Cook, Sahana Rao, Ting Zhou, Tuo Zhang, Zhaoying Xiang, Reyn Kenyon, Omer Kaymakcalan, Chengyang Liu, Todd Evans, Shuibing Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/aa6907d977454e5fb768c8afd2a10055
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spelling oai:doaj.org-article:aa6907d977454e5fb768c8afd2a100552021-12-02T14:16:47ZROCKII inhibition promotes the maturation of human pancreatic beta-like cells10.1038/s41467-017-00129-y2041-1723https://doaj.org/article/aa6907d977454e5fb768c8afd2a100552017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00129-yhttps://doaj.org/toc/2041-1723Our incomplete understanding of how pancreatic beta cells form limits the generation of beta-like cells from human pluripotent stem cells (hPSC). Here, the authors identify a ROCKII inhibitor H1152 as increasing insulin secreting cells from hPSCs and improving beta-cell maturation on transplantation in vivo.Zaniar GhazizadehDer-I KaoSadaf AminBrandoch CookSahana RaoTing ZhouTuo ZhangZhaoying XiangReyn KenyonOmer KaymakcalanChengyang LiuTodd EvansShuibing ChenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zaniar Ghazizadeh
Der-I Kao
Sadaf Amin
Brandoch Cook
Sahana Rao
Ting Zhou
Tuo Zhang
Zhaoying Xiang
Reyn Kenyon
Omer Kaymakcalan
Chengyang Liu
Todd Evans
Shuibing Chen
ROCKII inhibition promotes the maturation of human pancreatic beta-like cells
description Our incomplete understanding of how pancreatic beta cells form limits the generation of beta-like cells from human pluripotent stem cells (hPSC). Here, the authors identify a ROCKII inhibitor H1152 as increasing insulin secreting cells from hPSCs and improving beta-cell maturation on transplantation in vivo.
format article
author Zaniar Ghazizadeh
Der-I Kao
Sadaf Amin
Brandoch Cook
Sahana Rao
Ting Zhou
Tuo Zhang
Zhaoying Xiang
Reyn Kenyon
Omer Kaymakcalan
Chengyang Liu
Todd Evans
Shuibing Chen
author_facet Zaniar Ghazizadeh
Der-I Kao
Sadaf Amin
Brandoch Cook
Sahana Rao
Ting Zhou
Tuo Zhang
Zhaoying Xiang
Reyn Kenyon
Omer Kaymakcalan
Chengyang Liu
Todd Evans
Shuibing Chen
author_sort Zaniar Ghazizadeh
title ROCKII inhibition promotes the maturation of human pancreatic beta-like cells
title_short ROCKII inhibition promotes the maturation of human pancreatic beta-like cells
title_full ROCKII inhibition promotes the maturation of human pancreatic beta-like cells
title_fullStr ROCKII inhibition promotes the maturation of human pancreatic beta-like cells
title_full_unstemmed ROCKII inhibition promotes the maturation of human pancreatic beta-like cells
title_sort rockii inhibition promotes the maturation of human pancreatic beta-like cells
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/aa6907d977454e5fb768c8afd2a10055
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