Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation

Man Yang,1,2 Li Jing,1,2 Ji Wang,1,2 Yang Yu,1,2 Lige Cao,1,2 Lianshuang Zhang,1,2 Xianqing Zhou,1,2 Zhiwei Sun1,2 1School of Public Health, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Be...

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Autores principales:	Yang M, Jing L, Wang J, Yu Y, Cao L, Zhang L, Zhou X, Sun Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Silica nanoparticles Inflammation Macrophages Mechanism Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/aa69426f6b794cbbab19fcccbd3db3bf
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spelling	oai:doaj.org-article:aa69426f6b794cbbab19fcccbd3db3bf2021-12-02T00:38:48ZMacrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation1178-2013https://doaj.org/article/aa69426f6b794cbbab19fcccbd3db3bf2016-11-01T00:00:00Zhttps://www.dovepress.com/macrophages-participate-in-local-and-systemic-inflammation-induced-by--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Man Yang,1,2 Li Jing,1,2 Ji Wang,1,2 Yang Yu,1,2 Lige Cao,1,2 Lianshuang Zhang,1,2 Xianqing Zhou,1,2 Zhiwei Sun1,2 1School of Public Health, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China Abstract: Silica nanoparticles (SiNPs) are amongst the most commonly used materials in the field of nanomedicine and, therefore, their influence on organisms has drawn increasing attention in recent years. Most reports have focused on the single tissue reactions induced by SiNPs. Herein, the reaction of primary organs to SiNPs following intratracheal instillation in mice was analyzed by histopathology and ultrastructure observation. Following elucidation of the role of macrophages in local and systemic inflammation, the underlying mechanisms were explored using a macrophage cell line in vitro. The results suggest that macrophages swallow the SiNPs and secrete inflammatory factors by activating the NLRP3 inflammasome, thus participating in local and systemic inflammation. Keywords: silica nanoparticles, inflammation, macrophages, organs, NLRP3 inflammasomeYang MJing LWang JYu YCao LZhang LZhou XSun ZDove Medical PressarticleSilica nanoparticlesInflammationMacrophagesMechanismMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 6217-6228 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Silica nanoparticles Inflammation Macrophages Mechanism Medicine (General) R5-920
spellingShingle	Silica nanoparticles Inflammation Macrophages Mechanism Medicine (General) R5-920 Yang M Jing L Wang J Yu Y Cao L Zhang L Zhou X Sun Z Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation
description	Man Yang,1,2 Li Jing,1,2 Ji Wang,1,2 Yang Yu,1,2 Lige Cao,1,2 Lianshuang Zhang,1,2 Xianqing Zhou,1,2 Zhiwei Sun1,2 1School of Public Health, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China Abstract: Silica nanoparticles (SiNPs) are amongst the most commonly used materials in the field of nanomedicine and, therefore, their influence on organisms has drawn increasing attention in recent years. Most reports have focused on the single tissue reactions induced by SiNPs. Herein, the reaction of primary organs to SiNPs following intratracheal instillation in mice was analyzed by histopathology and ultrastructure observation. Following elucidation of the role of macrophages in local and systemic inflammation, the underlying mechanisms were explored using a macrophage cell line in vitro. The results suggest that macrophages swallow the SiNPs and secrete inflammatory factors by activating the NLRP3 inflammasome, thus participating in local and systemic inflammation. Keywords: silica nanoparticles, inflammation, macrophages, organs, NLRP3 inflammasome
format	article
author	Yang M Jing L Wang J Yu Y Cao L Zhang L Zhou X Sun Z
author_facet	Yang M Jing L Wang J Yu Y Cao L Zhang L Zhou X Sun Z
author_sort	Yang M
title	Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation
title_short	Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation
title_full	Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation
title_fullStr	Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation
title_full_unstemmed	Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation
title_sort	macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/aa69426f6b794cbbab19fcccbd3db3bf
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Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation

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