SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan

Valosin-Containing Protein (VCP) is linked to diverse degenerative diseases. Here, the authors show that Small VCP Interacting Protein (SVIP) recruits VCP to lysosomes, with gain and loss of SVIP muscle expression modifying neural degeneration, animal behaviour and lifespan.

Guardado en:

Detalles Bibliográficos
Autores principales:	Alyssa E. Johnson, Brian O. Orr, Richard D. Fetter, Armen J. Moughamian, Logan A. Primeaux, Ethan G. Geier, Jennifer S. Yokoyama, Bruce L. Miller, Graeme W. Davis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa6baecf1a634bae8c342d74ef2c74a7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aa6baecf1a634bae8c342d74ef2c74a7
record_format	dspace
spelling	oai:doaj.org-article:aa6baecf1a634bae8c342d74ef2c74a72021-12-02T13:56:46ZSVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan10.1038/s41467-020-20796-82041-1723https://doaj.org/article/aa6baecf1a634bae8c342d74ef2c74a72021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20796-8https://doaj.org/toc/2041-1723Valosin-Containing Protein (VCP) is linked to diverse degenerative diseases. Here, the authors show that Small VCP Interacting Protein (SVIP) recruits VCP to lysosomes, with gain and loss of SVIP muscle expression modifying neural degeneration, animal behaviour and lifespan.Alyssa E. JohnsonBrian O. OrrRichard D. FetterArmen J. MoughamianLogan A. PrimeauxEthan G. GeierJennifer S. YokoyamaBruce L. MillerGraeme W. DavisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alyssa E. Johnson Brian O. Orr Richard D. Fetter Armen J. Moughamian Logan A. Primeaux Ethan G. Geier Jennifer S. Yokoyama Bruce L. Miller Graeme W. Davis SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
description	Valosin-Containing Protein (VCP) is linked to diverse degenerative diseases. Here, the authors show that Small VCP Interacting Protein (SVIP) recruits VCP to lysosomes, with gain and loss of SVIP muscle expression modifying neural degeneration, animal behaviour and lifespan.
format	article
author	Alyssa E. Johnson Brian O. Orr Richard D. Fetter Armen J. Moughamian Logan A. Primeaux Ethan G. Geier Jennifer S. Yokoyama Bruce L. Miller Graeme W. Davis
author_facet	Alyssa E. Johnson Brian O. Orr Richard D. Fetter Armen J. Moughamian Logan A. Primeaux Ethan G. Geier Jennifer S. Yokoyama Bruce L. Miller Graeme W. Davis
author_sort	Alyssa E. Johnson
title	SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
title_short	SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
title_full	SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
title_fullStr	SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
title_full_unstemmed	SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
title_sort	svip is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa6baecf1a634bae8c342d74ef2c74a7
work_keys_str_mv	AT alyssaejohnson svipisamoleculardeterminantoflysosomaldynamicstabilityneurodegenerationandlifespan AT brianoorr svipisamoleculardeterminantoflysosomaldynamicstabilityneurodegenerationandlifespan AT richarddfetter svipisamoleculardeterminantoflysosomaldynamicstabilityneurodegenerationandlifespan AT armenjmoughamian svipisamoleculardeterminantoflysosomaldynamicstabilityneurodegenerationandlifespan AT loganaprimeaux svipisamoleculardeterminantoflysosomaldynamicstabilityneurodegenerationandlifespan AT ethanggeier svipisamoleculardeterminantoflysosomaldynamicstabilityneurodegenerationandlifespan AT jennifersyokoyama svipisamoleculardeterminantoflysosomaldynamicstabilityneurodegenerationandlifespan AT brucelmiller svipisamoleculardeterminantoflysosomaldynamicstabilityneurodegenerationandlifespan AT graemewdavis svipisamoleculardeterminantoflysosomaldynamicstabilityneurodegenerationandlifespan
_version_	1718392399258976256

SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan

Ejemplares similares