SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan

Valosin-Containing Protein (VCP) is linked to diverse degenerative diseases. Here, the authors show that Small VCP Interacting Protein (SVIP) recruits VCP to lysosomes, with gain and loss of SVIP muscle expression modifying neural degeneration, animal behaviour and lifespan.

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Main Authors:	Alyssa E. Johnson, Brian O. Orr, Richard D. Fetter, Armen J. Moughamian, Logan A. Primeaux, Ethan G. Geier, Jennifer S. Yokoyama, Bruce L. Miller, Graeme W. Davis
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/aa6baecf1a634bae8c342d74ef2c74a7
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spelling	oai:doaj.org-article:aa6baecf1a634bae8c342d74ef2c74a72021-12-02T13:56:46ZSVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan10.1038/s41467-020-20796-82041-1723https://doaj.org/article/aa6baecf1a634bae8c342d74ef2c74a72021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20796-8https://doaj.org/toc/2041-1723Valosin-Containing Protein (VCP) is linked to diverse degenerative diseases. Here, the authors show that Small VCP Interacting Protein (SVIP) recruits VCP to lysosomes, with gain and loss of SVIP muscle expression modifying neural degeneration, animal behaviour and lifespan.Alyssa E. JohnsonBrian O. OrrRichard D. FetterArmen J. MoughamianLogan A. PrimeauxEthan G. GeierJennifer S. YokoyamaBruce L. MillerGraeme W. DavisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alyssa E. Johnson Brian O. Orr Richard D. Fetter Armen J. Moughamian Logan A. Primeaux Ethan G. Geier Jennifer S. Yokoyama Bruce L. Miller Graeme W. Davis SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
description	Valosin-Containing Protein (VCP) is linked to diverse degenerative diseases. Here, the authors show that Small VCP Interacting Protein (SVIP) recruits VCP to lysosomes, with gain and loss of SVIP muscle expression modifying neural degeneration, animal behaviour and lifespan.
format	article
author	Alyssa E. Johnson Brian O. Orr Richard D. Fetter Armen J. Moughamian Logan A. Primeaux Ethan G. Geier Jennifer S. Yokoyama Bruce L. Miller Graeme W. Davis
author_facet	Alyssa E. Johnson Brian O. Orr Richard D. Fetter Armen J. Moughamian Logan A. Primeaux Ethan G. Geier Jennifer S. Yokoyama Bruce L. Miller Graeme W. Davis
author_sort	Alyssa E. Johnson
title	SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
title_short	SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
title_full	SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
title_fullStr	SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
title_full_unstemmed	SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
title_sort	svip is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa6baecf1a634bae8c342d74ef2c74a7
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SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan

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