NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function through chromatin remodeling and activation of gene expre...

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Autores principales:	Jennifer M. Peterson, David J. Wang, Vikram Shettigar, Steve R. Roof, Benjamin D. Canan, Nadine Bakkar, Jonathan Shintaku, Jin-Mo Gu, Sean C. Little, Nivedita M. Ratnam, Priya Londhe, Leina Lu, Christopher E. Gaw, Jennifer M. Petrosino, Sandya Liyanarachchi, Huating Wang, Paul M. L. Janssen, Jonathan P. Davis, Mark T. Ziolo, Sudarshana M. Sharma, Denis C. Guttridge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa724b3e4c7b4ada9b67a708841b1195
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spelling	oai:doaj.org-article:aa724b3e4c7b4ada9b67a708841b11952021-12-02T17:32:48ZNF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model10.1038/s41467-018-05910-12041-1723https://doaj.org/article/aa724b3e4c7b4ada9b67a708841b11952018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05910-1https://doaj.org/toc/2041-1723The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function through chromatin remodeling and activation of gene expression.Jennifer M. PetersonDavid J. WangVikram ShettigarSteve R. RoofBenjamin D. CananNadine BakkarJonathan ShintakuJin-Mo GuSean C. LittleNivedita M. RatnamPriya LondheLeina LuChristopher E. GawJennifer M. PetrosinoSandya LiyanarachchiHuating WangPaul M. L. JanssenJonathan P. DavisMark T. ZioloSudarshana M. SharmaDenis C. GuttridgeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer M. Peterson David J. Wang Vikram Shettigar Steve R. Roof Benjamin D. Canan Nadine Bakkar Jonathan Shintaku Jin-Mo Gu Sean C. Little Nivedita M. Ratnam Priya Londhe Leina Lu Christopher E. Gaw Jennifer M. Petrosino Sandya Liyanarachchi Huating Wang Paul M. L. Janssen Jonathan P. Davis Mark T. Ziolo Sudarshana M. Sharma Denis C. Guttridge NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model
description	The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function through chromatin remodeling and activation of gene expression.
format	article
author	Jennifer M. Peterson David J. Wang Vikram Shettigar Steve R. Roof Benjamin D. Canan Nadine Bakkar Jonathan Shintaku Jin-Mo Gu Sean C. Little Nivedita M. Ratnam Priya Londhe Leina Lu Christopher E. Gaw Jennifer M. Petrosino Sandya Liyanarachchi Huating Wang Paul M. L. Janssen Jonathan P. Davis Mark T. Ziolo Sudarshana M. Sharma Denis C. Guttridge
author_facet	Jennifer M. Peterson David J. Wang Vikram Shettigar Steve R. Roof Benjamin D. Canan Nadine Bakkar Jonathan Shintaku Jin-Mo Gu Sean C. Little Nivedita M. Ratnam Priya Londhe Leina Lu Christopher E. Gaw Jennifer M. Petrosino Sandya Liyanarachchi Huating Wang Paul M. L. Janssen Jonathan P. Davis Mark T. Ziolo Sudarshana M. Sharma Denis C. Guttridge
author_sort	Jennifer M. Peterson
title	NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model
title_short	NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model
title_full	NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model
title_fullStr	NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model
title_full_unstemmed	NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model
title_sort	nf-κb inhibition rescues cardiac function by remodeling calcium genes in a duchenne muscular dystrophy model
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/aa724b3e4c7b4ada9b67a708841b1195
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NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

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