Adult Lead Poisoning Caused by Contaminated Opium: A Two-Year Longitudinal Follow-Up Study

Background: A major episode of lead poisoning caused by lead-adulterated opium occurred in Iran in 2016. Patients were removed from exposure and treated with chelating agents. A subset of those patients was evaluated in this follow-up study to evaluate treatment efficacy in relation to patient outco...

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Autores principales:	Malihe-Sadat Hosseini, Amir Salimi, Scott Phillips, Nasim Zamani, Hossein Hassanian-Moghaddam
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2021
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/aa731647387d436699a4ab0d70a6a0fc
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spelling	oai:doaj.org-article:aa731647387d436699a4ab0d70a6a0fc2021-12-02T17:12:32ZAdult Lead Poisoning Caused by Contaminated Opium: A Two-Year Longitudinal Follow-Up Study2214-999610.5334/aogh.3420https://doaj.org/article/aa731647387d436699a4ab0d70a6a0fc2021-09-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/3420https://doaj.org/toc/2214-9996Background: A major episode of lead poisoning caused by lead-adulterated opium occurred in Iran in 2016. Patients were removed from exposure and treated with chelating agents. A subset of those patients was evaluated in this follow-up study to evaluate treatment efficacy in relation to patient outcome. Methods: Between March 2016 and December 2017, thirty-five male cases of lead poisoning due to ingestion of lead-adulterated opium were followed for two years. There are three patient groups: 1) those who abstained from opium use; 2) those who continued to use potentially contaminated opium; and 3) those who abstained from opium and were placed on maintenance therapy. Maintenance therapy included: methadone and opium tincture, offered by the Opioid Maintenance Therapy (OMT) clinics. Amongst the three patient groups Blood Lead Levels (BLL), complete blood count, and kidney and liver function tests were compared. Findings: The results of BLL, hemoglobin, hematocrit, and aspartate aminotransferase were significantly different between the admission time and follow-up. Of the three patient groups, no difference was detected in these measures. Conclusions: Treatment of lead poisoning combined with OMT proved an effective method to prevent recurrent lead poisoning.Malihe-Sadat HosseiniAmir SalimiScott PhillipsNasim ZamaniHossein Hassanian-MoghaddamUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 87, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Malihe-Sadat Hosseini Amir Salimi Scott Phillips Nasim Zamani Hossein Hassanian-Moghaddam Adult Lead Poisoning Caused by Contaminated Opium: A Two-Year Longitudinal Follow-Up Study
description	Background: A major episode of lead poisoning caused by lead-adulterated opium occurred in Iran in 2016. Patients were removed from exposure and treated with chelating agents. A subset of those patients was evaluated in this follow-up study to evaluate treatment efficacy in relation to patient outcome. Methods: Between March 2016 and December 2017, thirty-five male cases of lead poisoning due to ingestion of lead-adulterated opium were followed for two years. There are three patient groups: 1) those who abstained from opium use; 2) those who continued to use potentially contaminated opium; and 3) those who abstained from opium and were placed on maintenance therapy. Maintenance therapy included: methadone and opium tincture, offered by the Opioid Maintenance Therapy (OMT) clinics. Amongst the three patient groups Blood Lead Levels (BLL), complete blood count, and kidney and liver function tests were compared. Findings: The results of BLL, hemoglobin, hematocrit, and aspartate aminotransferase were significantly different between the admission time and follow-up. Of the three patient groups, no difference was detected in these measures. Conclusions: Treatment of lead poisoning combined with OMT proved an effective method to prevent recurrent lead poisoning.
format	article
author	Malihe-Sadat Hosseini Amir Salimi Scott Phillips Nasim Zamani Hossein Hassanian-Moghaddam
author_facet	Malihe-Sadat Hosseini Amir Salimi Scott Phillips Nasim Zamani Hossein Hassanian-Moghaddam
author_sort	Malihe-Sadat Hosseini
title	Adult Lead Poisoning Caused by Contaminated Opium: A Two-Year Longitudinal Follow-Up Study
title_short	Adult Lead Poisoning Caused by Contaminated Opium: A Two-Year Longitudinal Follow-Up Study
title_full	Adult Lead Poisoning Caused by Contaminated Opium: A Two-Year Longitudinal Follow-Up Study
title_fullStr	Adult Lead Poisoning Caused by Contaminated Opium: A Two-Year Longitudinal Follow-Up Study
title_full_unstemmed	Adult Lead Poisoning Caused by Contaminated Opium: A Two-Year Longitudinal Follow-Up Study
title_sort	adult lead poisoning caused by contaminated opium: a two-year longitudinal follow-up study
publisher	Ubiquity Press
publishDate	2021
url	https://doaj.org/article/aa731647387d436699a4ab0d70a6a0fc
work_keys_str_mv	AT malihesadathosseini adultleadpoisoningcausedbycontaminatedopiumatwoyearlongitudinalfollowupstudy AT amirsalimi adultleadpoisoningcausedbycontaminatedopiumatwoyearlongitudinalfollowupstudy AT scottphillips adultleadpoisoningcausedbycontaminatedopiumatwoyearlongitudinalfollowupstudy AT nasimzamani adultleadpoisoningcausedbycontaminatedopiumatwoyearlongitudinalfollowupstudy AT hosseinhassanianmoghaddam adultleadpoisoningcausedbycontaminatedopiumatwoyearlongitudinalfollowupstudy
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Adult Lead Poisoning Caused by Contaminated Opium: A Two-Year Longitudinal Follow-Up Study

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