Nanomedicine strategies for treatment of secondary spinal cord injury

Désirée White-Schenk,1,4 Riyi Shi,1–3 James F Leary1–4 1Interdisciplinary Biomedical Sciences Program, 2Weldon School of Biomedical Engineering, 3Department of Basic Medical Sciences, Lynn School of Veterinary Medicine, 4Birck Nanotechnology Center, Discov...

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Autores principales:	White-Schenk D, Shi R, Leary JF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/aa733038255645479b26611356270d23
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spelling	oai:doaj.org-article:aa733038255645479b26611356270d232021-12-02T08:20:22ZNanomedicine strategies for treatment of secondary spinal cord injury1178-2013https://doaj.org/article/aa733038255645479b26611356270d232015-01-01T00:00:00Zhttp://www.dovepress.com/nanomedicine-strategies-for-treatment-of-secondary-spinal-cord-injury-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Désirée White-Schenk,1,4 Riyi Shi,1–3 James F Leary1–4 1Interdisciplinary Biomedical Sciences Program, 2Weldon School of Biomedical Engineering, 3Department of Basic Medical Sciences, Lynn School of Veterinary Medicine, 4Birck Nanotechnology Center, Discovery Park, Purdue University, West Lafayette, IN, USA Abstract: Neurological injury, such as spinal cord injury, has a secondary injury associated with it. The secondary injury results from the biological cascade after the primary injury and affects previous uninjured, healthy tissue. Therefore, the mitigation of such a cascade would benefit patients suffering a primary injury and allow the body to recover more quickly. Unfortunately, the delivery of effective therapeutics is quite limited. Due to the inefficient delivery of therapeutic drugs, nanoparticles have become a major field of exploration for medical applications. Based on their material properties, they can help treat disease by delivering drugs to specific tissues, enhancing detection methods, or a mixture of both. Incorporating nanomedicine into the treatment of neuronal injury and disease would likely push nanomedicine into a new light. This review highlights the various pathological issues involved in secondary spinal cord injury, current treatment options, and the improvements that could be made using a nanomedical approach. Keywords: spinal cord injury, acrolein, drug delivery, methylprednisolone, secondary injuryWhite-Schenk DShi RLeary JFDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 923-938 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 White-Schenk D Shi R Leary JF Nanomedicine strategies for treatment of secondary spinal cord injury
description	Désirée White-Schenk,1,4 Riyi Shi,1–3 James F Leary1–4 1Interdisciplinary Biomedical Sciences Program, 2Weldon School of Biomedical Engineering, 3Department of Basic Medical Sciences, Lynn School of Veterinary Medicine, 4Birck Nanotechnology Center, Discovery Park, Purdue University, West Lafayette, IN, USA Abstract: Neurological injury, such as spinal cord injury, has a secondary injury associated with it. The secondary injury results from the biological cascade after the primary injury and affects previous uninjured, healthy tissue. Therefore, the mitigation of such a cascade would benefit patients suffering a primary injury and allow the body to recover more quickly. Unfortunately, the delivery of effective therapeutics is quite limited. Due to the inefficient delivery of therapeutic drugs, nanoparticles have become a major field of exploration for medical applications. Based on their material properties, they can help treat disease by delivering drugs to specific tissues, enhancing detection methods, or a mixture of both. Incorporating nanomedicine into the treatment of neuronal injury and disease would likely push nanomedicine into a new light. This review highlights the various pathological issues involved in secondary spinal cord injury, current treatment options, and the improvements that could be made using a nanomedical approach. Keywords: spinal cord injury, acrolein, drug delivery, methylprednisolone, secondary injury
format	article
author	White-Schenk D Shi R Leary JF
author_facet	White-Schenk D Shi R Leary JF
author_sort	White-Schenk D
title	Nanomedicine strategies for treatment of secondary spinal cord injury
title_short	Nanomedicine strategies for treatment of secondary spinal cord injury
title_full	Nanomedicine strategies for treatment of secondary spinal cord injury
title_fullStr	Nanomedicine strategies for treatment of secondary spinal cord injury
title_full_unstemmed	Nanomedicine strategies for treatment of secondary spinal cord injury
title_sort	nanomedicine strategies for treatment of secondary spinal cord injury
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/aa733038255645479b26611356270d23
work_keys_str_mv	AT whiteschenkd nanomedicinestrategiesfortreatmentofsecondaryspinalcordinjury AT shir nanomedicinestrategiesfortreatmentofsecondaryspinalcordinjury AT learyjf nanomedicinestrategiesfortreatmentofsecondaryspinalcordinjury
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Nanomedicine strategies for treatment of secondary spinal cord injury

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