Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles

An acyl radical generation and functionalization strategy through direct photoexcitation of benzothiazolines has been developed. The formed acyl radical species can either be trapped by quinoxalin-2-ones to realize their C(3)-H functionalization or trigger a cascade radical cyclization with isonitri...

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Auteurs principaux:	Xiang-Kui He, Juan Lu, Hai-Bing Ye, Lei Li, Jun Xuan
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	benzothiazolines photochemistry heterocycles Organic chemistry QD241-441
Accès en ligne:	https://doaj.org/article/aa78739c72704517bb086a35cdbc1812
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spelling	oai:doaj.org-article:aa78739c72704517bb086a35cdbc18122021-11-25T18:27:42ZDirect Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles10.3390/molecules262268431420-3049https://doaj.org/article/aa78739c72704517bb086a35cdbc18122021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6843https://doaj.org/toc/1420-3049An acyl radical generation and functionalization strategy through direct photoexcitation of benzothiazolines has been developed. The formed acyl radical species can either be trapped by quinoxalin-2-ones to realize their C(3)-H functionalization or trigger a cascade radical cyclization with isonitriles to synthesise biologically important phenanthridines. The synthetic value of this protocol can be further illustrated by the modification of quinoxalin-2-ones, containing important natural products and drug-based complex molecules.Xiang-Kui HeJuan LuHai-Bing YeLei LiJun XuanMDPI AGarticlebenzothiazolinesphotochemistryheterocyclesOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6843, p 6843 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	benzothiazolines photochemistry heterocycles Organic chemistry QD241-441
spellingShingle	benzothiazolines photochemistry heterocycles Organic chemistry QD241-441 Xiang-Kui He Juan Lu Hai-Bing Ye Lei Li Jun Xuan Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles
description	An acyl radical generation and functionalization strategy through direct photoexcitation of benzothiazolines has been developed. The formed acyl radical species can either be trapped by quinoxalin-2-ones to realize their C(3)-H functionalization or trigger a cascade radical cyclization with isonitriles to synthesise biologically important phenanthridines. The synthetic value of this protocol can be further illustrated by the modification of quinoxalin-2-ones, containing important natural products and drug-based complex molecules.
format	article
author	Xiang-Kui He Juan Lu Hai-Bing Ye Lei Li Jun Xuan
author_facet	Xiang-Kui He Juan Lu Hai-Bing Ye Lei Li Jun Xuan
author_sort	Xiang-Kui He
title	Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles
title_short	Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles
title_full	Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles
title_fullStr	Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles
title_full_unstemmed	Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles
title_sort	direct photoexcitation of benzothiazolines: acyl radical generation and application to access heterocycles
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/aa78739c72704517bb086a35cdbc1812
work_keys_str_mv	AT xiangkuihe directphotoexcitationofbenzothiazolinesacylradicalgenerationandapplicationtoaccessheterocycles AT juanlu directphotoexcitationofbenzothiazolinesacylradicalgenerationandapplicationtoaccessheterocycles AT haibingye directphotoexcitationofbenzothiazolinesacylradicalgenerationandapplicationtoaccessheterocycles AT leili directphotoexcitationofbenzothiazolinesacylradicalgenerationandapplicationtoaccessheterocycles AT junxuan directphotoexcitationofbenzothiazolinesacylradicalgenerationandapplicationtoaccessheterocycles
_version_	1718411151041101824

Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles

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