Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years

Abstract Dupuytren’s disease (DD) is a fibroproliferative disorder affecting the palmar fascia of the hand. Risk factors include diabetes mellitus (DM), whereas a high body mass index (BMI) is associated with a lower prevalence of DD. The aim of this study was to further elucidate risk and protectiv...

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Autores principales:	Mattias Rydberg, Malin Zimmerman, Jin Persson Löfgren, Anders Gottsäter, Peter M. Nilsson, Olle Melander, Lars B. Dahlin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa7ed37aa27d4d5db879d70fd52fdaaa
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spelling	oai:doaj.org-article:aa7ed37aa27d4d5db879d70fd52fdaaa2021-12-02T16:26:38ZMetabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years10.1038/s41598-021-94025-72045-2322https://doaj.org/article/aa7ed37aa27d4d5db879d70fd52fdaaa2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94025-7https://doaj.org/toc/2045-2322Abstract Dupuytren’s disease (DD) is a fibroproliferative disorder affecting the palmar fascia of the hand. Risk factors include diabetes mellitus (DM), whereas a high body mass index (BMI) is associated with a lower prevalence of DD. The aim of this study was to further elucidate risk and protective factors for the development of DD using longitudinal population-based data from the Malmö Diet and Cancer Study (MDCS). During 1991–1996, the inhabitants aged 46–73 years in the city of Malmö, Sweden were invited to participate in the population-based MDCS (41% participation rate). Data on incident DD were retrieved from Swedish national registers. Associations between DM, alcohol consumption, BMI, and serum apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) at baseline were analysed in multivariable Cox regression models adjusted for known confounders. Among 30,446 recruited participants, 347 men and 194 women were diagnosed with DD during a median follow-up time of 23 years. DM (men HR 2.23; 95% CI 1.50–3.30, women HR 2.69; 95% CI 1.48–4.90) and alcohol consumption (men HR 2.46; 95% CI 1.85–3.27, women HR 3.56; 95% CI 1.95–6.50) were independently associated with incident DD in the Cox regression models. Furthermore, inverse associations with incident DD were found for obesity among men, and ApoB/ApoA1 ratio among both sexes. DM and excess alcohol consumption constituted major risk factors for the development of DD. Furthermore, an inverse association between obesity among men and DD, and also between ApoB/ApoA1 ratio and DD was found in both sexes.Mattias RydbergMalin ZimmermanJin Persson LöfgrenAnders GottsäterPeter M. NilssonOlle MelanderLars B. DahlinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mattias Rydberg Malin Zimmerman Jin Persson Löfgren Anders Gottsäter Peter M. Nilsson Olle Melander Lars B. Dahlin Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years
description	Abstract Dupuytren’s disease (DD) is a fibroproliferative disorder affecting the palmar fascia of the hand. Risk factors include diabetes mellitus (DM), whereas a high body mass index (BMI) is associated with a lower prevalence of DD. The aim of this study was to further elucidate risk and protective factors for the development of DD using longitudinal population-based data from the Malmö Diet and Cancer Study (MDCS). During 1991–1996, the inhabitants aged 46–73 years in the city of Malmö, Sweden were invited to participate in the population-based MDCS (41% participation rate). Data on incident DD were retrieved from Swedish national registers. Associations between DM, alcohol consumption, BMI, and serum apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) at baseline were analysed in multivariable Cox regression models adjusted for known confounders. Among 30,446 recruited participants, 347 men and 194 women were diagnosed with DD during a median follow-up time of 23 years. DM (men HR 2.23; 95% CI 1.50–3.30, women HR 2.69; 95% CI 1.48–4.90) and alcohol consumption (men HR 2.46; 95% CI 1.85–3.27, women HR 3.56; 95% CI 1.95–6.50) were independently associated with incident DD in the Cox regression models. Furthermore, inverse associations with incident DD were found for obesity among men, and ApoB/ApoA1 ratio among both sexes. DM and excess alcohol consumption constituted major risk factors for the development of DD. Furthermore, an inverse association between obesity among men and DD, and also between ApoB/ApoA1 ratio and DD was found in both sexes.
format	article
author	Mattias Rydberg Malin Zimmerman Jin Persson Löfgren Anders Gottsäter Peter M. Nilsson Olle Melander Lars B. Dahlin
author_facet	Mattias Rydberg Malin Zimmerman Jin Persson Löfgren Anders Gottsäter Peter M. Nilsson Olle Melander Lars B. Dahlin
author_sort	Mattias Rydberg
title	Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years
title_short	Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years
title_full	Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years
title_fullStr	Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years
title_full_unstemmed	Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years
title_sort	metabolic factors and the risk of dupuytren’s disease: data from 30,000 individuals followed for over 20 years
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa7ed37aa27d4d5db879d70fd52fdaaa
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Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years

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