Reversible glycosidic switch for secure delivery of molecular nanocargos

Retention of drugs loaded into liposomes is a major challenge to effective targeted drug delivery. Here, the authors report on the modification of drugs with a glycosidic pH sensitive switch to improve encapsulation and retention of drugs and demonstrate application in an in vivo cancer model.

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Autores principales:	Pierre-Alain Burnouf, Yu-Lin Leu, Yu-Cheng Su, Kenneth Wu, Wei-Chi Lin, Steve R. Roffler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa7fda93c0384e18b7110be71bab9bfa
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spelling	oai:doaj.org-article:aa7fda93c0384e18b7110be71bab9bfa2021-12-02T14:39:24ZReversible glycosidic switch for secure delivery of molecular nanocargos10.1038/s41467-018-04225-52041-1723https://doaj.org/article/aa7fda93c0384e18b7110be71bab9bfa2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04225-5https://doaj.org/toc/2041-1723Retention of drugs loaded into liposomes is a major challenge to effective targeted drug delivery. Here, the authors report on the modification of drugs with a glycosidic pH sensitive switch to improve encapsulation and retention of drugs and demonstrate application in an in vivo cancer model.Pierre-Alain BurnoufYu-Lin LeuYu-Cheng SuKenneth WuWei-Chi LinSteve R. RofflerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pierre-Alain Burnouf Yu-Lin Leu Yu-Cheng Su Kenneth Wu Wei-Chi Lin Steve R. Roffler Reversible glycosidic switch for secure delivery of molecular nanocargos
description	Retention of drugs loaded into liposomes is a major challenge to effective targeted drug delivery. Here, the authors report on the modification of drugs with a glycosidic pH sensitive switch to improve encapsulation and retention of drugs and demonstrate application in an in vivo cancer model.
format	article
author	Pierre-Alain Burnouf Yu-Lin Leu Yu-Cheng Su Kenneth Wu Wei-Chi Lin Steve R. Roffler
author_facet	Pierre-Alain Burnouf Yu-Lin Leu Yu-Cheng Su Kenneth Wu Wei-Chi Lin Steve R. Roffler
author_sort	Pierre-Alain Burnouf
title	Reversible glycosidic switch for secure delivery of molecular nanocargos
title_short	Reversible glycosidic switch for secure delivery of molecular nanocargos
title_full	Reversible glycosidic switch for secure delivery of molecular nanocargos
title_fullStr	Reversible glycosidic switch for secure delivery of molecular nanocargos
title_full_unstemmed	Reversible glycosidic switch for secure delivery of molecular nanocargos
title_sort	reversible glycosidic switch for secure delivery of molecular nanocargos
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/aa7fda93c0384e18b7110be71bab9bfa
work_keys_str_mv	AT pierrealainburnouf reversibleglycosidicswitchforsecuredeliveryofmolecularnanocargos AT yulinleu reversibleglycosidicswitchforsecuredeliveryofmolecularnanocargos AT yuchengsu reversibleglycosidicswitchforsecuredeliveryofmolecularnanocargos AT kennethwu reversibleglycosidicswitchforsecuredeliveryofmolecularnanocargos AT weichilin reversibleglycosidicswitchforsecuredeliveryofmolecularnanocargos AT steverroffler reversibleglycosidicswitchforsecuredeliveryofmolecularnanocargos
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Reversible glycosidic switch for secure delivery of molecular nanocargos

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