Modeling restoration of gefitinib efficacy by co‐administration of MET inhibitors in an EGFR inhibitor‐resistant NSCLC xenograft model: A tumor‐in‐host DEB‐based approach
Abstract MET receptor tyrosine kinase inhibitors (TKIs) can restore sensitivity to gefitinib, a TKI targeting epidermal growth factor receptor (EGFR), and promote apoptosis in non‐small cell lung cancer (NSCLC) models resistant to gefitinib treatment in vitro and in vivo. Several novel MET inhibitor...
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Autores principales: | , , , , , |
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Formato: | article |
Lenguaje: | EN |
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Wiley
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/aa833859fc9044a780546843b278ac28 |
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