An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness

Antibiotics are commonly used in the Intensive Care Unit (ICU); however, several studies showed that the impact of antibiotics to prevent infection, multi-organ failure, and death in the ICU is less clear than their benefit on course of infection in the absence of organ dysfunction. We characterized...

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Autores principales:	Andrea Marfil-Sánchez, Lu Zhang, Pol Alonso-Pernas, Mohammad Mirhakkak, Melinda Mueller, Bastian Seelbinder, Yueqiong Ni, Rakesh Santhanam, Anne Busch, Christine Beemelmanns, Maria Ermolaeva, Michael Bauer, Gianni Panagiotou
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	gut microbiota antibiotics critical illness intensive care unit metagenomics metabolomics its2 Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/aa87bc94a1fb48ea8392831d68f0aae0
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spelling	oai:doaj.org-article:aa87bc94a1fb48ea8392831d68f0aae02021-11-26T11:19:48ZAn integrative understanding of the large metabolic shifts induced by antibiotics in critical illness1949-09761949-098410.1080/19490976.2021.1993598https://doaj.org/article/aa87bc94a1fb48ea8392831d68f0aae02021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19490976.2021.1993598https://doaj.org/toc/1949-0976https://doaj.org/toc/1949-0984Antibiotics are commonly used in the Intensive Care Unit (ICU); however, several studies showed that the impact of antibiotics to prevent infection, multi-organ failure, and death in the ICU is less clear than their benefit on course of infection in the absence of organ dysfunction. We characterized here the compositional and metabolic changes of the gut microbiome induced by critical illness and antibiotics in a cohort of 75 individuals in conjunction with 2,180 gut microbiome samples representing 16 different diseases. We revealed an “infection-vulnerable” gut microbiome environment present only in critically ill treated with antibiotics (ICU+). Feeding of Caenorhabditis elegans with Bifidobacterium animalis and Lactobacillus crispatus, species that expanded in ICU+ patients, revealed a significant negative impact of these microbes on host viability and developmental homeostasis. These results suggest that antibiotic administration can dramatically impact essential functional activities in the gut related to immune responses more than critical illness itself, which might explain in part untoward effects of antibiotics in the critically ill.Andrea Marfil-SánchezLu ZhangPol Alonso-PernasMohammad MirhakkakMelinda MuellerBastian SeelbinderYueqiong NiRakesh SanthanamAnne BuschChristine BeemelmannsMaria ErmolaevaMichael BauerGianni PanagiotouTaylor & Francis Grouparticlegut microbiotaantibioticscritical illnessintensive care unitmetagenomicsmetabolomicsits2Diseases of the digestive system. GastroenterologyRC799-869ENGut Microbes, Vol 13, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gut microbiota antibiotics critical illness intensive care unit metagenomics metabolomics its2 Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	gut microbiota antibiotics critical illness intensive care unit metagenomics metabolomics its2 Diseases of the digestive system. Gastroenterology RC799-869 Andrea Marfil-Sánchez Lu Zhang Pol Alonso-Pernas Mohammad Mirhakkak Melinda Mueller Bastian Seelbinder Yueqiong Ni Rakesh Santhanam Anne Busch Christine Beemelmanns Maria Ermolaeva Michael Bauer Gianni Panagiotou An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness
description	Antibiotics are commonly used in the Intensive Care Unit (ICU); however, several studies showed that the impact of antibiotics to prevent infection, multi-organ failure, and death in the ICU is less clear than their benefit on course of infection in the absence of organ dysfunction. We characterized here the compositional and metabolic changes of the gut microbiome induced by critical illness and antibiotics in a cohort of 75 individuals in conjunction with 2,180 gut microbiome samples representing 16 different diseases. We revealed an “infection-vulnerable” gut microbiome environment present only in critically ill treated with antibiotics (ICU+). Feeding of Caenorhabditis elegans with Bifidobacterium animalis and Lactobacillus crispatus, species that expanded in ICU+ patients, revealed a significant negative impact of these microbes on host viability and developmental homeostasis. These results suggest that antibiotic administration can dramatically impact essential functional activities in the gut related to immune responses more than critical illness itself, which might explain in part untoward effects of antibiotics in the critically ill.
format	article
author	Andrea Marfil-Sánchez Lu Zhang Pol Alonso-Pernas Mohammad Mirhakkak Melinda Mueller Bastian Seelbinder Yueqiong Ni Rakesh Santhanam Anne Busch Christine Beemelmanns Maria Ermolaeva Michael Bauer Gianni Panagiotou
author_facet	Andrea Marfil-Sánchez Lu Zhang Pol Alonso-Pernas Mohammad Mirhakkak Melinda Mueller Bastian Seelbinder Yueqiong Ni Rakesh Santhanam Anne Busch Christine Beemelmanns Maria Ermolaeva Michael Bauer Gianni Panagiotou
author_sort	Andrea Marfil-Sánchez
title	An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness
title_short	An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness
title_full	An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness
title_fullStr	An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness
title_full_unstemmed	An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness
title_sort	integrative understanding of the large metabolic shifts induced by antibiotics in critical illness
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/aa87bc94a1fb48ea8392831d68f0aae0
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An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness

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