Edible plant-derived essential oils synergistically enhance the Th1, Th2 and anti-inflammatory cytokines in neonatal cord blood monocytic cell line

Edible medicinal plants Curcuma longa, Kaempferia galanga and Zingiber officinale are considered to be suitable for pregnant mother and neonates. Their essential oils are claimed to have therapeutic effects, yet its immunomodulatory activities need to be investigated. To validate the immunomodulator...

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Autores principales:	Swagatika Dash, Monalisa Ray, Reena Parida, K. Gopinath Achary, Sanghamitra Nayak, Shikha Singh
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	curcuma longa kaempferia galanga zingiber officinale cbmcs neonatal cytokines immunostimulation Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/aa88121d2fe544f6b7f2d1da9d375f2c
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spelling	oai:doaj.org-article:aa88121d2fe544f6b7f2d1da9d375f2c2021-11-26T11:19:46ZEdible plant-derived essential oils synergistically enhance the Th1, Th2 and anti-inflammatory cytokines in neonatal cord blood monocytic cell line0954-01051465-344310.1080/09540105.2017.1376039https://doaj.org/article/aa88121d2fe544f6b7f2d1da9d375f2c2018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2017.1376039https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Edible medicinal plants Curcuma longa, Kaempferia galanga and Zingiber officinale are considered to be suitable for pregnant mother and neonates. Their essential oils are claimed to have therapeutic effects, yet its immunomodulatory activities need to be investigated. To validate the immunomodulatory effect, cord blood monocyte cells (CBMCs) treated with different concentrations of essential oils ranging from 0 to 40 µg/ml. K. galanga oil at 40 µg/ml concentrations upregulated IFN-γ at 49.23 pg/ml, while C. longa oil downregulated the IL-10 at 10.45 pg/ml showing immunostimulant activity on CBMCs. However, Z. officinale oil showed no significant result at any concentration. K. galanga and C. longa oils also showed an increase in lymphocyte proliferation in a dose-dependent manner. The present study was aimed to evaluate the immunomodulatory potentialities of essential oils which will attract the interest of researchers and pharmaceutical industries for clinical studies and other applications in the therapy of diseases related to neonatal infections.Swagatika DashMonalisa RayReena ParidaK. Gopinath AcharySanghamitra NayakShikha SinghTaylor & Francis Grouparticlecurcuma longakaempferia galangazingiber officinalecbmcsneonatal cytokinesimmunostimulationAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 346-357 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	curcuma longa kaempferia galanga zingiber officinale cbmcs neonatal cytokines immunostimulation Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	curcuma longa kaempferia galanga zingiber officinale cbmcs neonatal cytokines immunostimulation Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Swagatika Dash Monalisa Ray Reena Parida K. Gopinath Achary Sanghamitra Nayak Shikha Singh Edible plant-derived essential oils synergistically enhance the Th1, Th2 and anti-inflammatory cytokines in neonatal cord blood monocytic cell line
description	Edible medicinal plants Curcuma longa, Kaempferia galanga and Zingiber officinale are considered to be suitable for pregnant mother and neonates. Their essential oils are claimed to have therapeutic effects, yet its immunomodulatory activities need to be investigated. To validate the immunomodulatory effect, cord blood monocyte cells (CBMCs) treated with different concentrations of essential oils ranging from 0 to 40 µg/ml. K. galanga oil at 40 µg/ml concentrations upregulated IFN-γ at 49.23 pg/ml, while C. longa oil downregulated the IL-10 at 10.45 pg/ml showing immunostimulant activity on CBMCs. However, Z. officinale oil showed no significant result at any concentration. K. galanga and C. longa oils also showed an increase in lymphocyte proliferation in a dose-dependent manner. The present study was aimed to evaluate the immunomodulatory potentialities of essential oils which will attract the interest of researchers and pharmaceutical industries for clinical studies and other applications in the therapy of diseases related to neonatal infections.
format	article
author	Swagatika Dash Monalisa Ray Reena Parida K. Gopinath Achary Sanghamitra Nayak Shikha Singh
author_facet	Swagatika Dash Monalisa Ray Reena Parida K. Gopinath Achary Sanghamitra Nayak Shikha Singh
author_sort	Swagatika Dash
title	Edible plant-derived essential oils synergistically enhance the Th1, Th2 and anti-inflammatory cytokines in neonatal cord blood monocytic cell line
title_short	Edible plant-derived essential oils synergistically enhance the Th1, Th2 and anti-inflammatory cytokines in neonatal cord blood monocytic cell line
title_full	Edible plant-derived essential oils synergistically enhance the Th1, Th2 and anti-inflammatory cytokines in neonatal cord blood monocytic cell line
title_fullStr	Edible plant-derived essential oils synergistically enhance the Th1, Th2 and anti-inflammatory cytokines in neonatal cord blood monocytic cell line
title_full_unstemmed	Edible plant-derived essential oils synergistically enhance the Th1, Th2 and anti-inflammatory cytokines in neonatal cord blood monocytic cell line
title_sort	edible plant-derived essential oils synergistically enhance the th1, th2 and anti-inflammatory cytokines in neonatal cord blood monocytic cell line
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/aa88121d2fe544f6b7f2d1da9d375f2c
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Edible plant-derived essential oils synergistically enhance the Th1, Th2 and anti-inflammatory cytokines in neonatal cord blood monocytic cell line

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