Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux

Lin et al. investigate the use of CRISPRi technology in haloarchaea to regulate the metabolic pathways related to PHBV synthesis to increase PHBV production in H. mediterranei. The authors report that repression of citrate synthase genes redirects metabolic flux and increases production of this degr...

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Autores principales:	Lin Lin, Junyu Chen, Ruchira Mitra, Quanxiu Gao, Feiyue Cheng, Tong Xu, Zhenqiang Zuo, Hua Xiang, Jing Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/aa8868c2eed04a57a92cf82e318bfd90
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spelling	oai:doaj.org-article:aa8868c2eed04a57a92cf82e318bfd902021-12-02T15:09:14ZOptimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux10.1038/s42003-021-02541-z2399-3642https://doaj.org/article/aa8868c2eed04a57a92cf82e318bfd902021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02541-zhttps://doaj.org/toc/2399-3642Lin et al. investigate the use of CRISPRi technology in haloarchaea to regulate the metabolic pathways related to PHBV synthesis to increase PHBV production in H. mediterranei. The authors report that repression of citrate synthase genes redirects metabolic flux and increases production of this degradable bioplastic, which could be used as an alternative to chemical synthetic plastic.Lin LinJunyu ChenRuchira MitraQuanxiu GaoFeiyue ChengTong XuZhenqiang ZuoHua XiangJing HanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Lin Lin Junyu Chen Ruchira Mitra Quanxiu Gao Feiyue Cheng Tong Xu Zhenqiang Zuo Hua Xiang Jing Han Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux
description	Lin et al. investigate the use of CRISPRi technology in haloarchaea to regulate the metabolic pathways related to PHBV synthesis to increase PHBV production in H. mediterranei. The authors report that repression of citrate synthase genes redirects metabolic flux and increases production of this degradable bioplastic, which could be used as an alternative to chemical synthetic plastic.
format	article
author	Lin Lin Junyu Chen Ruchira Mitra Quanxiu Gao Feiyue Cheng Tong Xu Zhenqiang Zuo Hua Xiang Jing Han
author_facet	Lin Lin Junyu Chen Ruchira Mitra Quanxiu Gao Feiyue Cheng Tong Xu Zhenqiang Zuo Hua Xiang Jing Han
author_sort	Lin Lin
title	Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux
title_short	Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux
title_full	Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux
title_fullStr	Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux
title_full_unstemmed	Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux
title_sort	optimising phbv biopolymer production in haloarchaea via crispri-mediated redirection of carbon flux
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa8868c2eed04a57a92cf82e318bfd90
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Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux

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