No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study

Abstract Available evidence linking serum uric acid (SUA) and bone mineral density (BMD) remains controversial, and data on this association are limited among adult men in the general population. Thus, the aim of this study was to evaluate the association of SUA with lumbar spine BMD in US adult mal...

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Autores principales:	Xiaoli Li, Lianju Li, Lixian Yang, Jiaxun Yang, Hua Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa88fe89d2964d728865e870957e7ec0
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spelling	oai:doaj.org-article:aa88fe89d2964d728865e870957e7ec02021-12-02T17:06:32ZNo association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study10.1038/s41598-021-95207-z2045-2322https://doaj.org/article/aa88fe89d2964d728865e870957e7ec02021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95207-zhttps://doaj.org/toc/2045-2322Abstract Available evidence linking serum uric acid (SUA) and bone mineral density (BMD) remains controversial, and data on this association are limited among adult men in the general population. Thus, the aim of this study was to evaluate the association of SUA with lumbar spine BMD in US adult males. A cross-sectional study was conducted based on the National Health and Nutrition Examination Survey (NHANES, 1999–2006) database. Multivariate linear regression analyses were employed to assess the association of SUA with lumbar spine BMD, considering complex survey design and sampling weights. Through rigorous eligibility criteria, a total of 6704 individuals were yielded for final data analysis (average age, 40.5 years; 70.6% white). After fully adjusting potential confounders, no associations were detected between SUA and lumbar spine BMD [β (95% confidence interval, CI), − 0.003 (− 0.007, 0.002)]. Additionally, similar results were observed in all stratification analyses, and no interactions were found based on all priori specifications. In brief, our findings did not provide an inspiring clue for the hypothesis that SUA may be beneficial to lumbar spine BMD. Future more prospective studies are needed to further explore the causal relationship of SUA with lumbar spine BMD.Xiaoli LiLianju LiLixian YangJiaxun YangHua LuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoli Li Lianju Li Lixian Yang Jiaxun Yang Hua Lu No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study
description	Abstract Available evidence linking serum uric acid (SUA) and bone mineral density (BMD) remains controversial, and data on this association are limited among adult men in the general population. Thus, the aim of this study was to evaluate the association of SUA with lumbar spine BMD in US adult males. A cross-sectional study was conducted based on the National Health and Nutrition Examination Survey (NHANES, 1999–2006) database. Multivariate linear regression analyses were employed to assess the association of SUA with lumbar spine BMD, considering complex survey design and sampling weights. Through rigorous eligibility criteria, a total of 6704 individuals were yielded for final data analysis (average age, 40.5 years; 70.6% white). After fully adjusting potential confounders, no associations were detected between SUA and lumbar spine BMD [β (95% confidence interval, CI), − 0.003 (− 0.007, 0.002)]. Additionally, similar results were observed in all stratification analyses, and no interactions were found based on all priori specifications. In brief, our findings did not provide an inspiring clue for the hypothesis that SUA may be beneficial to lumbar spine BMD. Future more prospective studies are needed to further explore the causal relationship of SUA with lumbar spine BMD.
format	article
author	Xiaoli Li Lianju Li Lixian Yang Jiaxun Yang Hua Lu
author_facet	Xiaoli Li Lianju Li Lixian Yang Jiaxun Yang Hua Lu
author_sort	Xiaoli Li
title	No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study
title_short	No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study
title_full	No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study
title_fullStr	No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study
title_full_unstemmed	No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study
title_sort	no association between serum uric acid and lumbar spine bone mineral density in us adult males: a cross sectional study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa88fe89d2964d728865e870957e7ec0
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No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study

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