Scheduled feeding restores memory and modulates c-Fos expression in the suprachiasmatic nucleus and septohippocampal complex

Abstract Disruptions in circadian timing impair spatial memory in humans and rodents. Circadian-arrhythmic Siberian hamsters (Phodopus sungorus) exhibit substantial deficits in spatial working memory as assessed by a spontaneous alternation (SA) task. The present study found that daily scheduled fee...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Norman F. Ruby, Nathan Fisher, Danica F. Patton, Matthew J. Paul, Fabian Fernandez, H. Craig Heller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa8e073d532b495997ce14d5abffec17
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aa8e073d532b495997ce14d5abffec17
record_format	dspace
spelling	oai:doaj.org-article:aa8e073d532b495997ce14d5abffec172021-12-02T11:52:42ZScheduled feeding restores memory and modulates c-Fos expression in the suprachiasmatic nucleus and septohippocampal complex10.1038/s41598-017-06963-w2045-2322https://doaj.org/article/aa8e073d532b495997ce14d5abffec172017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06963-whttps://doaj.org/toc/2045-2322Abstract Disruptions in circadian timing impair spatial memory in humans and rodents. Circadian-arrhythmic Siberian hamsters (Phodopus sungorus) exhibit substantial deficits in spatial working memory as assessed by a spontaneous alternation (SA) task. The present study found that daily scheduled feeding rescued spatial memory deficits in these arrhythmic animals. Improvements in memory persisted for at least 3 weeks after the arrhythmic hamsters were switched back to ad libitum feeding. During ad libitum feeding, locomotor activity resumed its arrhythmic state, but performance on the SA task varied across the day with a peak in daily performance that corresponded to the previous daily window of food anticipation. At the end of scheduled feeding, c-Fos brain mapping revealed differential gene expression in entrained versus arrhythmic hamsters in the suprachiasmatic nucleus (SCN) that paralleled changes in the medial septum and hippocampus, but not in other neural structures. These data show that scheduled feeding can improve cognitive performance when SCN timing has been compromised, possibly by coordinating activity in the SCN and septohippocampal pathway.Norman F. RubyNathan FisherDanica F. PattonMatthew J. PaulFabian FernandezH. Craig HellerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Norman F. Ruby Nathan Fisher Danica F. Patton Matthew J. Paul Fabian Fernandez H. Craig Heller Scheduled feeding restores memory and modulates c-Fos expression in the suprachiasmatic nucleus and septohippocampal complex
description	Abstract Disruptions in circadian timing impair spatial memory in humans and rodents. Circadian-arrhythmic Siberian hamsters (Phodopus sungorus) exhibit substantial deficits in spatial working memory as assessed by a spontaneous alternation (SA) task. The present study found that daily scheduled feeding rescued spatial memory deficits in these arrhythmic animals. Improvements in memory persisted for at least 3 weeks after the arrhythmic hamsters were switched back to ad libitum feeding. During ad libitum feeding, locomotor activity resumed its arrhythmic state, but performance on the SA task varied across the day with a peak in daily performance that corresponded to the previous daily window of food anticipation. At the end of scheduled feeding, c-Fos brain mapping revealed differential gene expression in entrained versus arrhythmic hamsters in the suprachiasmatic nucleus (SCN) that paralleled changes in the medial septum and hippocampus, but not in other neural structures. These data show that scheduled feeding can improve cognitive performance when SCN timing has been compromised, possibly by coordinating activity in the SCN and septohippocampal pathway.
format	article
author	Norman F. Ruby Nathan Fisher Danica F. Patton Matthew J. Paul Fabian Fernandez H. Craig Heller
author_facet	Norman F. Ruby Nathan Fisher Danica F. Patton Matthew J. Paul Fabian Fernandez H. Craig Heller
author_sort	Norman F. Ruby
title	Scheduled feeding restores memory and modulates c-Fos expression in the suprachiasmatic nucleus and septohippocampal complex
title_short	Scheduled feeding restores memory and modulates c-Fos expression in the suprachiasmatic nucleus and septohippocampal complex
title_full	Scheduled feeding restores memory and modulates c-Fos expression in the suprachiasmatic nucleus and septohippocampal complex
title_fullStr	Scheduled feeding restores memory and modulates c-Fos expression in the suprachiasmatic nucleus and septohippocampal complex
title_full_unstemmed	Scheduled feeding restores memory and modulates c-Fos expression in the suprachiasmatic nucleus and septohippocampal complex
title_sort	scheduled feeding restores memory and modulates c-fos expression in the suprachiasmatic nucleus and septohippocampal complex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/aa8e073d532b495997ce14d5abffec17
work_keys_str_mv	AT normanfruby scheduledfeedingrestoresmemoryandmodulatescfosexpressioninthesuprachiasmaticnucleusandseptohippocampalcomplex AT nathanfisher scheduledfeedingrestoresmemoryandmodulatescfosexpressioninthesuprachiasmaticnucleusandseptohippocampalcomplex AT danicafpatton scheduledfeedingrestoresmemoryandmodulatescfosexpressioninthesuprachiasmaticnucleusandseptohippocampalcomplex AT matthewjpaul scheduledfeedingrestoresmemoryandmodulatescfosexpressioninthesuprachiasmaticnucleusandseptohippocampalcomplex AT fabianfernandez scheduledfeedingrestoresmemoryandmodulatescfosexpressioninthesuprachiasmaticnucleusandseptohippocampalcomplex AT hcraigheller scheduledfeedingrestoresmemoryandmodulatescfosexpressioninthesuprachiasmaticnucleusandseptohippocampalcomplex
_version_	1718394945113423872

Scheduled feeding restores memory and modulates c-Fos expression in the suprachiasmatic nucleus and septohippocampal complex

Ejemplares similares