Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators

Here, combing the massive gene-universe of the gut microbiome to identify strain-specific, cross-disease, associations across seven human diseases, the authors introduce the concept of microbiome architecture, defined as the complete set of positive and negative associations between microbial genes...

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Autores principales:	Braden T. Tierney, Yingxuan Tan, Aleksandar D. Kostic, Chirag J. Patel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa92ba967fec46d998689080a37ed860
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spelling	oai:doaj.org-article:aa92ba967fec46d998689080a37ed8602021-12-02T15:45:24ZGene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators10.1038/s41467-021-23029-82041-1723https://doaj.org/article/aa92ba967fec46d998689080a37ed8602021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23029-8https://doaj.org/toc/2041-1723Here, combing the massive gene-universe of the gut microbiome to identify strain-specific, cross-disease, associations across seven human diseases, the authors introduce the concept of microbiome architecture, defined as the complete set of positive and negative associations between microbial genes and human host disease, highlighting microbiome architectures as potential diagnostic indicators.Braden T. TierneyYingxuan TanAleksandar D. KosticChirag J. PatelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Braden T. Tierney Yingxuan Tan Aleksandar D. Kostic Chirag J. Patel Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators
description	Here, combing the massive gene-universe of the gut microbiome to identify strain-specific, cross-disease, associations across seven human diseases, the authors introduce the concept of microbiome architecture, defined as the complete set of positive and negative associations between microbial genes and human host disease, highlighting microbiome architectures as potential diagnostic indicators.
format	article
author	Braden T. Tierney Yingxuan Tan Aleksandar D. Kostic Chirag J. Patel
author_facet	Braden T. Tierney Yingxuan Tan Aleksandar D. Kostic Chirag J. Patel
author_sort	Braden T. Tierney
title	Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators
title_short	Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators
title_full	Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators
title_fullStr	Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators
title_full_unstemmed	Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators
title_sort	gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa92ba967fec46d998689080a37ed860
work_keys_str_mv	AT bradenttierney genelevelmetagenomicarchitecturesacrossdiseasesyieldhighresolutionmicrobiomediagnosticindicators AT yingxuantan genelevelmetagenomicarchitecturesacrossdiseasesyieldhighresolutionmicrobiomediagnosticindicators AT aleksandardkostic genelevelmetagenomicarchitecturesacrossdiseasesyieldhighresolutionmicrobiomediagnosticindicators AT chiragjpatel genelevelmetagenomicarchitecturesacrossdiseasesyieldhighresolutionmicrobiomediagnosticindicators
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Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators

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