Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation

Several mechanisms of resistance to T cell-engaging therapies have been described for solid tumors. Here, by using T cell bispecific antibodies and chimeric antigen receptors (CAR) T cells targeting HER2, the authors show that cancer cell intrinsic disruption of interferon-gamma signalling, includin...

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Autores principales:	Enrique J. Arenas, Alex Martínez-Sabadell, Irene Rius Ruiz, Macarena Román Alonso, Marta Escorihuela, Antonio Luque, Carlos Alberto Fajardo, Alena Gros, Christian Klein, Joaquín Arribas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa94e03a034246f68048ebc589ddfa65
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spelling	oai:doaj.org-article:aa94e03a034246f68048ebc589ddfa652021-12-02T10:59:14ZAcquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation10.1038/s41467-021-21445-42041-1723https://doaj.org/article/aa94e03a034246f68048ebc589ddfa652021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21445-4https://doaj.org/toc/2041-1723Several mechanisms of resistance to T cell-engaging therapies have been described for solid tumors. Here, by using T cell bispecific antibodies and chimeric antigen receptors (CAR) T cells targeting HER2, the authors show that cancer cell intrinsic disruption of interferon-gamma signalling, including downregulation of JAK2, confers resistance to T-cell mediated cytotoxicity.Enrique J. ArenasAlex Martínez-SabadellIrene Rius RuizMacarena Román AlonsoMarta EscorihuelaAntonio LuqueCarlos Alberto FajardoAlena GrosChristian KleinJoaquín ArribasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Enrique J. Arenas Alex Martínez-Sabadell Irene Rius Ruiz Macarena Román Alonso Marta Escorihuela Antonio Luque Carlos Alberto Fajardo Alena Gros Christian Klein Joaquín Arribas Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation
description	Several mechanisms of resistance to T cell-engaging therapies have been described for solid tumors. Here, by using T cell bispecific antibodies and chimeric antigen receptors (CAR) T cells targeting HER2, the authors show that cancer cell intrinsic disruption of interferon-gamma signalling, including downregulation of JAK2, confers resistance to T-cell mediated cytotoxicity.
format	article
author	Enrique J. Arenas Alex Martínez-Sabadell Irene Rius Ruiz Macarena Román Alonso Marta Escorihuela Antonio Luque Carlos Alberto Fajardo Alena Gros Christian Klein Joaquín Arribas
author_facet	Enrique J. Arenas Alex Martínez-Sabadell Irene Rius Ruiz Macarena Román Alonso Marta Escorihuela Antonio Luque Carlos Alberto Fajardo Alena Gros Christian Klein Joaquín Arribas
author_sort	Enrique J. Arenas
title	Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation
title_short	Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation
title_full	Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation
title_fullStr	Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation
title_full_unstemmed	Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation
title_sort	acquired cancer cell resistance to t cell bispecific antibodies and car t targeting her2 through jak2 down-modulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa94e03a034246f68048ebc589ddfa65
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Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation

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