C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair

Hereditary mutations in TTDA/GTF2H5 cause a photosensitive form of the rare developmental disorder trichothiodystrophy, however the development of models has been hampered by mutations being lethal. Thijssen et al. show that deficiency of C. elegans TTDA ortholog GTF-2H5 is, compatible with life, in...

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Autores principales:	Karen L. Thijssen, Melanie van der Woude, Carlota Davó-Martínez, Dick H. W. Dekkers, Mariangela Sabatella, Jeroen A. A. Demmers, Wim Vermeulen, Hannes Lans
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/aa9b284b2d79417c957d8200b1542823
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spelling	oai:doaj.org-article:aa9b284b2d79417c957d8200b15428232021-11-28T12:10:26ZC. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair10.1038/s42003-021-02875-82399-3642https://doaj.org/article/aa9b284b2d79417c957d8200b15428232021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02875-8https://doaj.org/toc/2399-3642Hereditary mutations in TTDA/GTF2H5 cause a photosensitive form of the rare developmental disorder trichothiodystrophy, however the development of models has been hampered by mutations being lethal. Thijssen et al. show that deficiency of C. elegans TTDA ortholog GTF-2H5 is, compatible with life, in contrast to depletion of other TFIIH subunits and thus propose that this model could be used for studying the pathogenesis of trichothiodystrophy.Karen L. ThijssenMelanie van der WoudeCarlota Davó-MartínezDick H. W. DekkersMariangela SabatellaJeroen A. A. DemmersWim VermeulenHannes LansNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Karen L. Thijssen Melanie van der Woude Carlota Davó-Martínez Dick H. W. Dekkers Mariangela Sabatella Jeroen A. A. Demmers Wim Vermeulen Hannes Lans C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair
description	Hereditary mutations in TTDA/GTF2H5 cause a photosensitive form of the rare developmental disorder trichothiodystrophy, however the development of models has been hampered by mutations being lethal. Thijssen et al. show that deficiency of C. elegans TTDA ortholog GTF-2H5 is, compatible with life, in contrast to depletion of other TFIIH subunits and thus propose that this model could be used for studying the pathogenesis of trichothiodystrophy.
format	article
author	Karen L. Thijssen Melanie van der Woude Carlota Davó-Martínez Dick H. W. Dekkers Mariangela Sabatella Jeroen A. A. Demmers Wim Vermeulen Hannes Lans
author_facet	Karen L. Thijssen Melanie van der Woude Carlota Davó-Martínez Dick H. W. Dekkers Mariangela Sabatella Jeroen A. A. Demmers Wim Vermeulen Hannes Lans
author_sort	Karen L. Thijssen
title	C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair
title_short	C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair
title_full	C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair
title_fullStr	C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair
title_full_unstemmed	C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair
title_sort	c. elegans tfiih subunit gtf-2h5/ttda is a non-essential transcription factor indispensable for dna repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa9b284b2d79417c957d8200b1542823
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C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair

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