Structural basis of host protein hijacking in human T-cell leukemia virus integration

Integration of the reverse-transcribed viral DNA into host chromosomes is a critical step in the life-cycle of retroviruses such as the human T-cell leukemia virus type-1 (HTLV-1). Here the authors describe the structural role of the host co-factor protein phosphatase 2A B56γ subunit in supporting i...

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Autores principales:	Veer Bhatt, Ke Shi, Daniel J. Salamango, Nicholas H. Moeller, Krishan K. Pandey, Sibes Bera, Thomas E. Bohl, Fredy Kurniawan, Kayo Orellana, Wei Zhang, Duane P. Grandgenett, Reuben S. Harris, Anna C. Sundborger-Lunna, Hideki Aihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa9b53faafb14e34a356550f154c5e2f
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spelling	oai:doaj.org-article:aa9b53faafb14e34a356550f154c5e2f2021-12-02T17:13:27ZStructural basis of host protein hijacking in human T-cell leukemia virus integration10.1038/s41467-020-16963-62041-1723https://doaj.org/article/aa9b53faafb14e34a356550f154c5e2f2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16963-6https://doaj.org/toc/2041-1723Integration of the reverse-transcribed viral DNA into host chromosomes is a critical step in the life-cycle of retroviruses such as the human T-cell leukemia virus type-1 (HTLV-1). Here the authors describe the structural role of the host co-factor protein phosphatase 2A B56γ subunit in supporting integration as part of the HTLV-1 intasome.Veer BhattKe ShiDaniel J. SalamangoNicholas H. MoellerKrishan K. PandeySibes BeraThomas E. BohlFredy KurniawanKayo OrellanaWei ZhangDuane P. GrandgenettReuben S. HarrisAnna C. Sundborger-LunnaHideki AiharaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Veer Bhatt Ke Shi Daniel J. Salamango Nicholas H. Moeller Krishan K. Pandey Sibes Bera Thomas E. Bohl Fredy Kurniawan Kayo Orellana Wei Zhang Duane P. Grandgenett Reuben S. Harris Anna C. Sundborger-Lunna Hideki Aihara Structural basis of host protein hijacking in human T-cell leukemia virus integration
description	Integration of the reverse-transcribed viral DNA into host chromosomes is a critical step in the life-cycle of retroviruses such as the human T-cell leukemia virus type-1 (HTLV-1). Here the authors describe the structural role of the host co-factor protein phosphatase 2A B56γ subunit in supporting integration as part of the HTLV-1 intasome.
format	article
author	Veer Bhatt Ke Shi Daniel J. Salamango Nicholas H. Moeller Krishan K. Pandey Sibes Bera Thomas E. Bohl Fredy Kurniawan Kayo Orellana Wei Zhang Duane P. Grandgenett Reuben S. Harris Anna C. Sundborger-Lunna Hideki Aihara
author_facet	Veer Bhatt Ke Shi Daniel J. Salamango Nicholas H. Moeller Krishan K. Pandey Sibes Bera Thomas E. Bohl Fredy Kurniawan Kayo Orellana Wei Zhang Duane P. Grandgenett Reuben S. Harris Anna C. Sundborger-Lunna Hideki Aihara
author_sort	Veer Bhatt
title	Structural basis of host protein hijacking in human T-cell leukemia virus integration
title_short	Structural basis of host protein hijacking in human T-cell leukemia virus integration
title_full	Structural basis of host protein hijacking in human T-cell leukemia virus integration
title_fullStr	Structural basis of host protein hijacking in human T-cell leukemia virus integration
title_full_unstemmed	Structural basis of host protein hijacking in human T-cell leukemia virus integration
title_sort	structural basis of host protein hijacking in human t-cell leukemia virus integration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/aa9b53faafb14e34a356550f154c5e2f
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Structural basis of host protein hijacking in human T-cell leukemia virus integration

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