Flexible search for single-axon morphology during neuronal spontaneous polarization.

Polarization, a disruption of symmetry in cellular morphology, occurs spontaneously, even in symmetrical extracellular conditions. This process is regulated by intracellular chemical reactions and the active transport of proteins and it is accompanied by cellular morphological changes. To elucidate...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Honda Naoki, Shinichi Nakamuta, Kozo Kaibuchi, Shin Ishii
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa9fd00e82384b4ab1d8277682509548
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aa9fd00e82384b4ab1d8277682509548
record_format	dspace
spelling	oai:doaj.org-article:aa9fd00e82384b4ab1d82776825095482021-11-18T06:54:39ZFlexible search for single-axon morphology during neuronal spontaneous polarization.1932-620310.1371/journal.pone.0019034https://doaj.org/article/aa9fd00e82384b4ab1d82776825095482011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21559492/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Polarization, a disruption of symmetry in cellular morphology, occurs spontaneously, even in symmetrical extracellular conditions. This process is regulated by intracellular chemical reactions and the active transport of proteins and it is accompanied by cellular morphological changes. To elucidate the general principles underlying polarization, we focused on developing neurons. Neuronal polarity is stably established; a neuron initially has several neurites of similar length, but only one elongates and is selected to develop into an axon. Polarization is flexibly controlled; when multiple neurites are selected, the selection is eventually reduced to yield a single axon. What is the system by which morphological information is decoded differently based on the presence of a single or multiple axons? How are stability and flexibility achieved? To answer these questions, we constructed a biophysical model with the active transport of proteins that regulate neurite growth. Our mathematical analysis and computer simulation revealed that, as neurites elongate, transported factors accumulate in the growth cone but are degraded during retrograde diffusion to the soma. Such a system effectively works as local activation-global inhibition mechanism, resulting in both stability and flexibility. Our model shows good accordance with a number of experimental observations.Honda NaokiShinichi NakamutaKozo KaibuchiShin IshiiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e19034 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Honda Naoki Shinichi Nakamuta Kozo Kaibuchi Shin Ishii Flexible search for single-axon morphology during neuronal spontaneous polarization.
description	Polarization, a disruption of symmetry in cellular morphology, occurs spontaneously, even in symmetrical extracellular conditions. This process is regulated by intracellular chemical reactions and the active transport of proteins and it is accompanied by cellular morphological changes. To elucidate the general principles underlying polarization, we focused on developing neurons. Neuronal polarity is stably established; a neuron initially has several neurites of similar length, but only one elongates and is selected to develop into an axon. Polarization is flexibly controlled; when multiple neurites are selected, the selection is eventually reduced to yield a single axon. What is the system by which morphological information is decoded differently based on the presence of a single or multiple axons? How are stability and flexibility achieved? To answer these questions, we constructed a biophysical model with the active transport of proteins that regulate neurite growth. Our mathematical analysis and computer simulation revealed that, as neurites elongate, transported factors accumulate in the growth cone but are degraded during retrograde diffusion to the soma. Such a system effectively works as local activation-global inhibition mechanism, resulting in both stability and flexibility. Our model shows good accordance with a number of experimental observations.
format	article
author	Honda Naoki Shinichi Nakamuta Kozo Kaibuchi Shin Ishii
author_facet	Honda Naoki Shinichi Nakamuta Kozo Kaibuchi Shin Ishii
author_sort	Honda Naoki
title	Flexible search for single-axon morphology during neuronal spontaneous polarization.
title_short	Flexible search for single-axon morphology during neuronal spontaneous polarization.
title_full	Flexible search for single-axon morphology during neuronal spontaneous polarization.
title_fullStr	Flexible search for single-axon morphology during neuronal spontaneous polarization.
title_full_unstemmed	Flexible search for single-axon morphology during neuronal spontaneous polarization.
title_sort	flexible search for single-axon morphology during neuronal spontaneous polarization.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/aa9fd00e82384b4ab1d8277682509548
work_keys_str_mv	AT hondanaoki flexiblesearchforsingleaxonmorphologyduringneuronalspontaneouspolarization AT shinichinakamuta flexiblesearchforsingleaxonmorphologyduringneuronalspontaneouspolarization AT kozokaibuchi flexiblesearchforsingleaxonmorphologyduringneuronalspontaneouspolarization AT shinishii flexiblesearchforsingleaxonmorphologyduringneuronalspontaneouspolarization
_version_	1718424247763730432

Flexible search for single-axon morphology during neuronal spontaneous polarization.

Ejemplares similares