Association between Statin Use and Sensorineural Hearing Loss in Type 2 Diabetic Patients: A Hospital-Based Study

Statins have emerged as protective agents against sensorineural hearing loss (SNHL) associated with dyslipidemia, but the effects of statins on SNHL are not consistent. The purpose of this study was to investigate the association between statin use and the risk of SNHL using a hospital cohort. This...

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Autores principales:	Hye-Won Han, Jeong Yee, Yoon-Hee Park, Hye-Sun Gwak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	statins sensorineural hearing loss tinnitus type 2 diabetic patients Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/aaa29dd338fd4191a1b94f38e2c0465f
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spelling	oai:doaj.org-article:aaa29dd338fd4191a1b94f38e2c0465f2021-11-25T18:39:08ZAssociation between Statin Use and Sensorineural Hearing Loss in Type 2 Diabetic Patients: A Hospital-Based Study10.3390/ph141110761424-8247https://doaj.org/article/aaa29dd338fd4191a1b94f38e2c0465f2021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1076https://doaj.org/toc/1424-8247Statins have emerged as protective agents against sensorineural hearing loss (SNHL) associated with dyslipidemia, but the effects of statins on SNHL are not consistent. The purpose of this study was to investigate the association between statin use and the risk of SNHL using a hospital cohort. This nested case-control study included type 2 diabetic patients over the age of 18 years without a history of hearing loss. Of these, 1379 patients newly diagnosed with SNHL or tinnitus were classified as cases, and 5512 patients matched to the cases based on age, sex, and index year were classified as controls. Chi-squared tests were used to compare categorical variables between the two groups. Odds ratios (ORs) and adjusted odds ratios (AOR) were calculated from univariate and multivariable unconditional logistic regression analyses, respectively. There was a significant difference in the prevalence of statin use between the cases and controls (53.7% vs. 61.2%, respectively; <i>p</i> < 0.001). The use of statins in type 2 diabetic patients significantly reduced the risk of SNHL or tinnitus by 24.8% (95% CI 14.2–34.1%, <i>p</i> < 0.001) after controlling for confounders. Similar results were found for the association between statin use and SNHL (AOR = 0.706; 95% CI 0.616–0.811, <i>p</i> < 0.001). The protective effects of statins against SNHL were consistent regardless of age and sex. The use of statins for type 2 diabetic patients was significantly associated with a reduced risk of SNHL, regardless of age and sex. Further studies are needed, especially large cohort studies, to evaluate the long-term protective effects of statins.Hye-Won HanJeong YeeYoon-Hee ParkHye-Sun GwakMDPI AGarticlestatinssensorineural hearing losstinnitustype 2 diabetic patientsMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1076, p 1076 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	statins sensorineural hearing loss tinnitus type 2 diabetic patients Medicine R Pharmacy and materia medica RS1-441
spellingShingle	statins sensorineural hearing loss tinnitus type 2 diabetic patients Medicine R Pharmacy and materia medica RS1-441 Hye-Won Han Jeong Yee Yoon-Hee Park Hye-Sun Gwak Association between Statin Use and Sensorineural Hearing Loss in Type 2 Diabetic Patients: A Hospital-Based Study
description	Statins have emerged as protective agents against sensorineural hearing loss (SNHL) associated with dyslipidemia, but the effects of statins on SNHL are not consistent. The purpose of this study was to investigate the association between statin use and the risk of SNHL using a hospital cohort. This nested case-control study included type 2 diabetic patients over the age of 18 years without a history of hearing loss. Of these, 1379 patients newly diagnosed with SNHL or tinnitus were classified as cases, and 5512 patients matched to the cases based on age, sex, and index year were classified as controls. Chi-squared tests were used to compare categorical variables between the two groups. Odds ratios (ORs) and adjusted odds ratios (AOR) were calculated from univariate and multivariable unconditional logistic regression analyses, respectively. There was a significant difference in the prevalence of statin use between the cases and controls (53.7% vs. 61.2%, respectively; <i>p</i> < 0.001). The use of statins in type 2 diabetic patients significantly reduced the risk of SNHL or tinnitus by 24.8% (95% CI 14.2–34.1%, <i>p</i> < 0.001) after controlling for confounders. Similar results were found for the association between statin use and SNHL (AOR = 0.706; 95% CI 0.616–0.811, <i>p</i> < 0.001). The protective effects of statins against SNHL were consistent regardless of age and sex. The use of statins for type 2 diabetic patients was significantly associated with a reduced risk of SNHL, regardless of age and sex. Further studies are needed, especially large cohort studies, to evaluate the long-term protective effects of statins.
format	article
author	Hye-Won Han Jeong Yee Yoon-Hee Park Hye-Sun Gwak
author_facet	Hye-Won Han Jeong Yee Yoon-Hee Park Hye-Sun Gwak
author_sort	Hye-Won Han
title	Association between Statin Use and Sensorineural Hearing Loss in Type 2 Diabetic Patients: A Hospital-Based Study
title_short	Association between Statin Use and Sensorineural Hearing Loss in Type 2 Diabetic Patients: A Hospital-Based Study
title_full	Association between Statin Use and Sensorineural Hearing Loss in Type 2 Diabetic Patients: A Hospital-Based Study
title_fullStr	Association between Statin Use and Sensorineural Hearing Loss in Type 2 Diabetic Patients: A Hospital-Based Study
title_full_unstemmed	Association between Statin Use and Sensorineural Hearing Loss in Type 2 Diabetic Patients: A Hospital-Based Study
title_sort	association between statin use and sensorineural hearing loss in type 2 diabetic patients: a hospital-based study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/aaa29dd338fd4191a1b94f38e2c0465f
work_keys_str_mv	AT hyewonhan associationbetweenstatinuseandsensorineuralhearinglossintype2diabeticpatientsahospitalbasedstudy AT jeongyee associationbetweenstatinuseandsensorineuralhearinglossintype2diabeticpatientsahospitalbasedstudy AT yoonheepark associationbetweenstatinuseandsensorineuralhearinglossintype2diabeticpatientsahospitalbasedstudy AT hyesungwak associationbetweenstatinuseandsensorineuralhearinglossintype2diabeticpatientsahospitalbasedstudy
_version_	1718410856447868928

Association between Statin Use and Sensorineural Hearing Loss in Type 2 Diabetic Patients: A Hospital-Based Study

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