Medication errors safety signals COVID-19-related Moroccan Pv database

On March 23, 2020, the Moroccan Ministry of Health issued a circular authorizing the off label use of hydroxychloroquine or chloroquine in combination with azythromycin as first-line treatment for all COVID-19 patients. The aim of this study is to detect, assess and manage safety signals from indivi...

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Autores principales:	Sefiani Houda, Benabdallah Ghita, Tebaa Amina, Soulaymani Bencheikh Rachida
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/aaa5f19496104d3c852ba4ae07945bcb
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spelling	oai:doaj.org-article:aaa5f19496104d3c852ba4ae07945bcb2021-12-02T17:11:26ZMedication errors safety signals COVID-19-related Moroccan Pv database2267-124210.1051/e3sconf/202131902025https://doaj.org/article/aaa5f19496104d3c852ba4ae07945bcb2021-01-01T00:00:00Zhttps://www.e3s-conferences.org/articles/e3sconf/pdf/2021/95/e3sconf_vigisan_02025.pdfhttps://doaj.org/toc/2267-1242On March 23, 2020, the Moroccan Ministry of Health issued a circular authorizing the off label use of hydroxychloroquine or chloroquine in combination with azythromycin as first-line treatment for all COVID-19 patients. The aim of this study is to detect, assess and manage safety signals from individual cardiovascular adverse events (AE) reported. Methods: During the COVID19 pandemic, pharmacovigilance surveillance was based on spontaneous targeted notification in all health facilities. Newsletters with a suitable reporting form were sent and reporting of AEs was mandatory. The AEs collected were analyzed for causality assessment using the WHO method and the Preventavility method was used to detect any preventable ADR. Safety signals were detected and analyzed using a qualitative pharmacovigilance method. Results: As of December 31, 2020, a total of 527 adverse events have been reported to the NPC related to Hydroxychloroquine or Chloroquine among the Covid 19 patients. We received 09 cases of preventable AEs related to medication error including one drug interaction for 3 cases, dose errors for 5 cases and one case with both errors, these cases have been validated ad managed as safety signals. Discussion and conclusion: The detected signal concerned the QT prolongation, hypokalaemia and arrythmias, due to high dose of azithromycin and to drug interactions with hypokalaemic drugs. The signal was analyzed and validated during the technical committee, and recommendations were established to avoid the occurrence of similar cases.Sefiani HoudaBenabdallah GhitaTebaa AminaSoulaymani Bencheikh RachidaEDP SciencesarticleEnvironmental sciencesGE1-350ENFRE3S Web of Conferences, Vol 319, p 02025 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	Environmental sciences GE1-350
spellingShingle	Environmental sciences GE1-350 Sefiani Houda Benabdallah Ghita Tebaa Amina Soulaymani Bencheikh Rachida Medication errors safety signals COVID-19-related Moroccan Pv database
description	On March 23, 2020, the Moroccan Ministry of Health issued a circular authorizing the off label use of hydroxychloroquine or chloroquine in combination with azythromycin as first-line treatment for all COVID-19 patients. The aim of this study is to detect, assess and manage safety signals from individual cardiovascular adverse events (AE) reported. Methods: During the COVID19 pandemic, pharmacovigilance surveillance was based on spontaneous targeted notification in all health facilities. Newsletters with a suitable reporting form were sent and reporting of AEs was mandatory. The AEs collected were analyzed for causality assessment using the WHO method and the Preventavility method was used to detect any preventable ADR. Safety signals were detected and analyzed using a qualitative pharmacovigilance method. Results: As of December 31, 2020, a total of 527 adverse events have been reported to the NPC related to Hydroxychloroquine or Chloroquine among the Covid 19 patients. We received 09 cases of preventable AEs related to medication error including one drug interaction for 3 cases, dose errors for 5 cases and one case with both errors, these cases have been validated ad managed as safety signals. Discussion and conclusion: The detected signal concerned the QT prolongation, hypokalaemia and arrythmias, due to high dose of azithromycin and to drug interactions with hypokalaemic drugs. The signal was analyzed and validated during the technical committee, and recommendations were established to avoid the occurrence of similar cases.
format	article
author	Sefiani Houda Benabdallah Ghita Tebaa Amina Soulaymani Bencheikh Rachida
author_facet	Sefiani Houda Benabdallah Ghita Tebaa Amina Soulaymani Bencheikh Rachida
author_sort	Sefiani Houda
title	Medication errors safety signals COVID-19-related Moroccan Pv database
title_short	Medication errors safety signals COVID-19-related Moroccan Pv database
title_full	Medication errors safety signals COVID-19-related Moroccan Pv database
title_fullStr	Medication errors safety signals COVID-19-related Moroccan Pv database
title_full_unstemmed	Medication errors safety signals COVID-19-related Moroccan Pv database
title_sort	medication errors safety signals covid-19-related moroccan pv database
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/aaa5f19496104d3c852ba4ae07945bcb
work_keys_str_mv	AT sefianihouda medicationerrorssafetysignalscovid19relatedmoroccanpvdatabase AT benabdallahghita medicationerrorssafetysignalscovid19relatedmoroccanpvdatabase AT tebaaamina medicationerrorssafetysignalscovid19relatedmoroccanpvdatabase AT soulaymanibencheikhrachida medicationerrorssafetysignalscovid19relatedmoroccanpvdatabase
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Medication errors safety signals COVID-19-related Moroccan Pv database

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