Age differences in brain signal variability are robust to multiple vascular controls

Abstract A host of studies support that younger, better performing adults express greater moment-to-moment blood oxygen level-dependent (BOLD) signal variability (SDBOLD) in various cortical regions, supporting an emerging view that the aging brain may undergo a generalized reduction in dynamic rang...

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Autores principales:	Douglas D. Garrett, Ulman Lindenberger, Richard D. Hoge, Claudine J. Gauthier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aaa6ca9b13cb4532971d70ceced52f74
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spelling	oai:doaj.org-article:aaa6ca9b13cb4532971d70ceced52f742021-12-02T15:06:15ZAge differences in brain signal variability are robust to multiple vascular controls10.1038/s41598-017-09752-72045-2322https://doaj.org/article/aaa6ca9b13cb4532971d70ceced52f742017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09752-7https://doaj.org/toc/2045-2322Abstract A host of studies support that younger, better performing adults express greater moment-to-moment blood oxygen level-dependent (BOLD) signal variability (SDBOLD) in various cortical regions, supporting an emerging view that the aging brain may undergo a generalized reduction in dynamic range. However, the exact physiological nature of age differences in SDBOLD remains understudied. In a sample of 29 younger and 45 older adults, we examined the contribution of vascular factors to age group differences in fixation-based SDBOLD using (1) a dual-echo BOLD/pseudo-continuous arterial spin labeling (pCASL) sequence, and (2) hypercapnia via a computer-controlled gas delivery system. We tested the hypothesis that, although SDBOLD may relate to individual differences in absolute cerebral blood flow (CBF), BOLD cerebrovascular reactivity (CVR), or maximum BOLD signal change (M), robust age differences in SDBOLD would remain after multiple statistical controls for these vascular factors. As expected, our results demonstrated that brain regions in which younger adults expressed higher SDBOLD persisted after comprehensive control of vascular effects. Our findings thus further establish BOLD signal variability as an important marker of the aging brain.Douglas D. GarrettUlman LindenbergerRichard D. HogeClaudine J. GauthierNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Douglas D. Garrett Ulman Lindenberger Richard D. Hoge Claudine J. Gauthier Age differences in brain signal variability are robust to multiple vascular controls
description	Abstract A host of studies support that younger, better performing adults express greater moment-to-moment blood oxygen level-dependent (BOLD) signal variability (SDBOLD) in various cortical regions, supporting an emerging view that the aging brain may undergo a generalized reduction in dynamic range. However, the exact physiological nature of age differences in SDBOLD remains understudied. In a sample of 29 younger and 45 older adults, we examined the contribution of vascular factors to age group differences in fixation-based SDBOLD using (1) a dual-echo BOLD/pseudo-continuous arterial spin labeling (pCASL) sequence, and (2) hypercapnia via a computer-controlled gas delivery system. We tested the hypothesis that, although SDBOLD may relate to individual differences in absolute cerebral blood flow (CBF), BOLD cerebrovascular reactivity (CVR), or maximum BOLD signal change (M), robust age differences in SDBOLD would remain after multiple statistical controls for these vascular factors. As expected, our results demonstrated that brain regions in which younger adults expressed higher SDBOLD persisted after comprehensive control of vascular effects. Our findings thus further establish BOLD signal variability as an important marker of the aging brain.
format	article
author	Douglas D. Garrett Ulman Lindenberger Richard D. Hoge Claudine J. Gauthier
author_facet	Douglas D. Garrett Ulman Lindenberger Richard D. Hoge Claudine J. Gauthier
author_sort	Douglas D. Garrett
title	Age differences in brain signal variability are robust to multiple vascular controls
title_short	Age differences in brain signal variability are robust to multiple vascular controls
title_full	Age differences in brain signal variability are robust to multiple vascular controls
title_fullStr	Age differences in brain signal variability are robust to multiple vascular controls
title_full_unstemmed	Age differences in brain signal variability are robust to multiple vascular controls
title_sort	age differences in brain signal variability are robust to multiple vascular controls
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/aaa6ca9b13cb4532971d70ceced52f74
work_keys_str_mv	AT douglasdgarrett agedifferencesinbrainsignalvariabilityarerobusttomultiplevascularcontrols AT ulmanlindenberger agedifferencesinbrainsignalvariabilityarerobusttomultiplevascularcontrols AT richarddhoge agedifferencesinbrainsignalvariabilityarerobusttomultiplevascularcontrols AT claudinejgauthier agedifferencesinbrainsignalvariabilityarerobusttomultiplevascularcontrols
_version_	1718388535730372608

Age differences in brain signal variability are robust to multiple vascular controls

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