Effect of Medium-Term Injection of MDMA on the Anxiety of Male Rat with plus Maze Test

BACKGROUND AND OBJECTIVE: Acute administration of Methylenedioxymethamphetamine (MDMA) is produced dose-dependent effects on anxiety-related behaviors. High doses of MDMA have anxiolytic effects and low doses of MDMA increases anxiety-like behavior in the elevated plus maze test. The aim of this stu...

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Autores principales:	M Jahanshahi, O Nikmahzar, M Khosravi, F Seid Hosseini
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	methylenedioxymethamphetamine anxiety elevated plus maze rat Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/aaa72fb8fe3740c3b1a4a1bfd4d93273
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spelling	oai:doaj.org-article:aaa72fb8fe3740c3b1a4a1bfd4d932732021-11-10T08:53:33ZEffect of Medium-Term Injection of MDMA on the Anxiety of Male Rat with plus Maze Test1561-41072251-7170https://doaj.org/article/aaa72fb8fe3740c3b1a4a1bfd4d932732012-11-01T00:00:00Zhttp://jbums.org/article-1-4231-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Acute administration of Methylenedioxymethamphetamine (MDMA) is produced dose-dependent effects on anxiety-related behaviors. High doses of MDMA have anxiolytic effects and low doses of MDMA increases anxiety-like behavior in the elevated plus maze test. The aim of this study was to evaluate the sub-chronic (7 days) effects of low doses of MDMA on anxiety in the male rat.METHODS: In the present experimental study, 28 male Wistar rats were used with approximate weight 20 ± 200 g. Animals were randomly divided into 4 groups, 7 rats were used in each group and experimental groups for a week received different doses of MDMA (1.25, 2.5, 5 mg/kg) and sham group (1 ml/kg), received saline peritoneally. Anxiety one day before injection and 30 minutes after the last injection was performed by the elevated plus maze.FINDINGS: Injection of MDMA significantly increased open arm time percentage that the highest observed in the experimental group received a dose of 5 mg/kg with mean 29.77±33.337. With increasing dose of MDMA increased open arm entry percentage that the difference between experimental group received a dose of 2.5 mg/kg and saline group was statistically significant (p<0.05). MDMA decreased pure index of locomotor activity. MDMA decreased open arm latency that the experimental group received a dose of 2.5 mg/kg less delay in entering the open arm compared to the other experimental groups, averaging 70.83±114.188 showed.CONCLUSION: Low doses of MDMA in sub-chronic (7 day) period can reduce some indices of anxiety in the rats.M Jahanshahi,O NikmahzarM KhosraviF Seid HosseiniBabol University of Medical Sciencesarticlemethylenedioxymethamphetamineanxietyelevated plus mazeratMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 6, Pp 84-90 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	methylenedioxymethamphetamine anxiety elevated plus maze rat Medicine R Medicine (General) R5-920
spellingShingle	methylenedioxymethamphetamine anxiety elevated plus maze rat Medicine R Medicine (General) R5-920 M Jahanshahi, O Nikmahzar M Khosravi F Seid Hosseini Effect of Medium-Term Injection of MDMA on the Anxiety of Male Rat with plus Maze Test
description	BACKGROUND AND OBJECTIVE: Acute administration of Methylenedioxymethamphetamine (MDMA) is produced dose-dependent effects on anxiety-related behaviors. High doses of MDMA have anxiolytic effects and low doses of MDMA increases anxiety-like behavior in the elevated plus maze test. The aim of this study was to evaluate the sub-chronic (7 days) effects of low doses of MDMA on anxiety in the male rat.METHODS: In the present experimental study, 28 male Wistar rats were used with approximate weight 20 ± 200 g. Animals were randomly divided into 4 groups, 7 rats were used in each group and experimental groups for a week received different doses of MDMA (1.25, 2.5, 5 mg/kg) and sham group (1 ml/kg), received saline peritoneally. Anxiety one day before injection and 30 minutes after the last injection was performed by the elevated plus maze.FINDINGS: Injection of MDMA significantly increased open arm time percentage that the highest observed in the experimental group received a dose of 5 mg/kg with mean 29.77±33.337. With increasing dose of MDMA increased open arm entry percentage that the difference between experimental group received a dose of 2.5 mg/kg and saline group was statistically significant (p<0.05). MDMA decreased pure index of locomotor activity. MDMA decreased open arm latency that the experimental group received a dose of 2.5 mg/kg less delay in entering the open arm compared to the other experimental groups, averaging 70.83±114.188 showed.CONCLUSION: Low doses of MDMA in sub-chronic (7 day) period can reduce some indices of anxiety in the rats.
format	article
author	M Jahanshahi, O Nikmahzar M Khosravi F Seid Hosseini
author_facet	M Jahanshahi, O Nikmahzar M Khosravi F Seid Hosseini
author_sort	M Jahanshahi,
title	Effect of Medium-Term Injection of MDMA on the Anxiety of Male Rat with plus Maze Test
title_short	Effect of Medium-Term Injection of MDMA on the Anxiety of Male Rat with plus Maze Test
title_full	Effect of Medium-Term Injection of MDMA on the Anxiety of Male Rat with plus Maze Test
title_fullStr	Effect of Medium-Term Injection of MDMA on the Anxiety of Male Rat with plus Maze Test
title_full_unstemmed	Effect of Medium-Term Injection of MDMA on the Anxiety of Male Rat with plus Maze Test
title_sort	effect of medium-term injection of mdma on the anxiety of male rat with plus maze test
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/aaa72fb8fe3740c3b1a4a1bfd4d93273
work_keys_str_mv	AT mjahanshahi effectofmediumterminjectionofmdmaontheanxietyofmaleratwithplusmazetest AT onikmahzar effectofmediumterminjectionofmdmaontheanxietyofmaleratwithplusmazetest AT mkhosravi effectofmediumterminjectionofmdmaontheanxietyofmaleratwithplusmazetest AT fseidhosseini effectofmediumterminjectionofmdmaontheanxietyofmaleratwithplusmazetest
_version_	1718440407187062784

Effect of Medium-Term Injection of MDMA on the Anxiety of Male Rat with plus Maze Test

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