Antidepressant medication use and nasopharyngeal cancer risk: a nationwide population-based study

Chiao-Fan Lin,1,2,* Hsiang-Lin Chan,1,2 Yi-Hsuan Hsieh,1,2 Hsin-Yi Liang,1,2 Wei-Che Chiu,3,4,* Yena Lee,5 Roger S McIntyre,5,6 Vincent Chin-Hung Chen2,7,81Department of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2Department of Psychiatry, Chang Gung University, Taoyuan,...

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Autores principales:	Lin C, Chan HL, Hsieh YH, Liang H, Chiu WC, Lee Y, McIntyre RS, Chen VC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	nasopharyngeal cancer antidepressants Taiwan national insurance Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/aaab33ffe2c04f7396cb42897ecb2d32
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spelling	oai:doaj.org-article:aaab33ffe2c04f7396cb42897ecb2d322021-12-02T07:22:46ZAntidepressant medication use and nasopharyngeal cancer risk: a nationwide population-based study1178-2021https://doaj.org/article/aaab33ffe2c04f7396cb42897ecb2d322018-04-01T00:00:00Zhttps://www.dovepress.com/antidepressant-medication-use-and-nasopharyngeal-cancer-risk-a-nationw-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Chiao-Fan Lin,1,2,* Hsiang-Lin Chan,1,2 Yi-Hsuan Hsieh,1,2 Hsin-Yi Liang,1,2 Wei-Che Chiu,3,4,* Yena Lee,5 Roger S McIntyre,5,6 Vincent Chin-Hung Chen2,7,81Department of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan; 3Department of Psychiatry, Cathay General Hospital, Taipei, Taiwan; 4School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, Taiwan; 5Mood Disorders Psychopharmacology Unit, Brain and Cognition Discovery Foundation, Toronto, Ontario, Canada; 6Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; 7Medical Research Department, Health Information and Epidemiology Laboratory, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; 8Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan*These authors contributed equally to this work Background: The association between antidepressant exposure and nasopharyngeal cancer (NPC) has not been previously explored. The purpose of this study was to investigate the association between antidepressant prescription, including novel antidepressants, and the risk of NPC in a population-based study.Materials and methods: Data for the analysis were derived from National Health Insurance Research Database. We identified 16,957 cases with a diagnosis of NPC and 83,231 matched controls by using a nested case–control design. A conditional logistic regression model was used, with adjustments for potentially confounding variables (eg, comorbid physical diseases, comorbid psychiatric diseases, and other medications).Results: We report no association between NPC incidence and antidepressant prescription. For all classes of antidepressants, antidepressant exposure, regardless of cumulative dose, had no significant effect on NPC incidence (adjusted odds ratio of cumulative selective serotonin reuptake inhibitor exposure ≥336 defined daily dose was 1.18 [95% CI: 0.90–1.53]; tricyclic antidepressant exposure ≥336 defined daily dose was 1.18 [95% CI: 0.80–1.74]).Conclusion: There was no association between antidepressant prescription and incident NPC.Keywords: nasopharyngeal cancer, antidepressants, Taiwan national insuranceLin CChan HLHsieh YHLiang HChiu WCLee YMcIntyre RSChen VCDove Medical Pressarticlenasopharyngeal cancerantidepressantsTaiwan national insuranceNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1101-1106 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	nasopharyngeal cancer antidepressants Taiwan national insurance Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	nasopharyngeal cancer antidepressants Taiwan national insurance Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lin C Chan HL Hsieh YH Liang H Chiu WC Lee Y McIntyre RS Chen VC Antidepressant medication use and nasopharyngeal cancer risk: a nationwide population-based study
description	Chiao-Fan Lin,1,2,* Hsiang-Lin Chan,1,2 Yi-Hsuan Hsieh,1,2 Hsin-Yi Liang,1,2 Wei-Che Chiu,3,4,* Yena Lee,5 Roger S McIntyre,5,6 Vincent Chin-Hung Chen2,7,81Department of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan; 3Department of Psychiatry, Cathay General Hospital, Taipei, Taiwan; 4School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, Taiwan; 5Mood Disorders Psychopharmacology Unit, Brain and Cognition Discovery Foundation, Toronto, Ontario, Canada; 6Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; 7Medical Research Department, Health Information and Epidemiology Laboratory, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; 8Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan*These authors contributed equally to this work Background: The association between antidepressant exposure and nasopharyngeal cancer (NPC) has not been previously explored. The purpose of this study was to investigate the association between antidepressant prescription, including novel antidepressants, and the risk of NPC in a population-based study.Materials and methods: Data for the analysis were derived from National Health Insurance Research Database. We identified 16,957 cases with a diagnosis of NPC and 83,231 matched controls by using a nested case–control design. A conditional logistic regression model was used, with adjustments for potentially confounding variables (eg, comorbid physical diseases, comorbid psychiatric diseases, and other medications).Results: We report no association between NPC incidence and antidepressant prescription. For all classes of antidepressants, antidepressant exposure, regardless of cumulative dose, had no significant effect on NPC incidence (adjusted odds ratio of cumulative selective serotonin reuptake inhibitor exposure ≥336 defined daily dose was 1.18 [95% CI: 0.90–1.53]; tricyclic antidepressant exposure ≥336 defined daily dose was 1.18 [95% CI: 0.80–1.74]).Conclusion: There was no association between antidepressant prescription and incident NPC.Keywords: nasopharyngeal cancer, antidepressants, Taiwan national insurance
format	article
author	Lin C Chan HL Hsieh YH Liang H Chiu WC Lee Y McIntyre RS Chen VC
author_facet	Lin C Chan HL Hsieh YH Liang H Chiu WC Lee Y McIntyre RS Chen VC
author_sort	Lin C
title	Antidepressant medication use and nasopharyngeal cancer risk: a nationwide population-based study
title_short	Antidepressant medication use and nasopharyngeal cancer risk: a nationwide population-based study
title_full	Antidepressant medication use and nasopharyngeal cancer risk: a nationwide population-based study
title_fullStr	Antidepressant medication use and nasopharyngeal cancer risk: a nationwide population-based study
title_full_unstemmed	Antidepressant medication use and nasopharyngeal cancer risk: a nationwide population-based study
title_sort	antidepressant medication use and nasopharyngeal cancer risk: a nationwide population-based study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/aaab33ffe2c04f7396cb42897ecb2d32
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Antidepressant medication use and nasopharyngeal cancer risk: a nationwide population-based study

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