KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary

Adult-type granulosa cell tumors of the ovary (aGCTs) are rare and recurrence is difficult to treat. Here, the authors observe in aGCT a novel recurrent somatic truncating mutation of KMT2D, more frequent in recurrent aGCT, and also non-genetic loss of KMT2D expression.

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Autores principales:	R. Tyler Hillman, Joseph Celestino, Christopher Terranova, Hannah C. Beird, Curtis Gumbs, Latasha Little, Tri Nguyen, Rebecca Thornton, Samantha Tippen, Jianhua Zhang, Karen H. Lu, David M. Gershenson, Kunal Rai, Russell R. Broaddus, P. Andrew Futreal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aaaf9455dfe54c3aac5bc54116b1802b
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spelling	oai:doaj.org-article:aaaf9455dfe54c3aac5bc54116b1802b2021-12-02T14:41:16ZKMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary10.1038/s41467-018-04950-x2041-1723https://doaj.org/article/aaaf9455dfe54c3aac5bc54116b1802b2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04950-xhttps://doaj.org/toc/2041-1723Adult-type granulosa cell tumors of the ovary (aGCTs) are rare and recurrence is difficult to treat. Here, the authors observe in aGCT a novel recurrent somatic truncating mutation of KMT2D, more frequent in recurrent aGCT, and also non-genetic loss of KMT2D expression.R. Tyler HillmanJoseph CelestinoChristopher TerranovaHannah C. BeirdCurtis GumbsLatasha LittleTri NguyenRebecca ThorntonSamantha TippenJianhua ZhangKaren H. LuDavid M. GershensonKunal RaiRussell R. BroaddusP. Andrew FutrealNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q R. Tyler Hillman Joseph Celestino Christopher Terranova Hannah C. Beird Curtis Gumbs Latasha Little Tri Nguyen Rebecca Thornton Samantha Tippen Jianhua Zhang Karen H. Lu David M. Gershenson Kunal Rai Russell R. Broaddus P. Andrew Futreal KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary
description	Adult-type granulosa cell tumors of the ovary (aGCTs) are rare and recurrence is difficult to treat. Here, the authors observe in aGCT a novel recurrent somatic truncating mutation of KMT2D, more frequent in recurrent aGCT, and also non-genetic loss of KMT2D expression.
format	article
author	R. Tyler Hillman Joseph Celestino Christopher Terranova Hannah C. Beird Curtis Gumbs Latasha Little Tri Nguyen Rebecca Thornton Samantha Tippen Jianhua Zhang Karen H. Lu David M. Gershenson Kunal Rai Russell R. Broaddus P. Andrew Futreal
author_facet	R. Tyler Hillman Joseph Celestino Christopher Terranova Hannah C. Beird Curtis Gumbs Latasha Little Tri Nguyen Rebecca Thornton Samantha Tippen Jianhua Zhang Karen H. Lu David M. Gershenson Kunal Rai Russell R. Broaddus P. Andrew Futreal
author_sort	R. Tyler Hillman
title	KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary
title_short	KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary
title_full	KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary
title_fullStr	KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary
title_full_unstemmed	KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary
title_sort	kmt2d/mll2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/aaaf9455dfe54c3aac5bc54116b1802b
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KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary

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