An apocrine mechanism delivers a fully immunocompetent exocrine secretion
Abstract Apocrine secretion is a recently discovered widespread non-canonical and non-vesicular secretory mechanism whose regulation and purpose is only partly defined. Here, we demonstrate that apocrine secretion in the prepupal salivary glands (SGs) of Drosophila provides the sole source of immune...
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Nature Portfolio
2021
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oai:doaj.org-article:aab0820c77334dbe82a686505ce70f342021-12-02T14:53:43ZAn apocrine mechanism delivers a fully immunocompetent exocrine secretion10.1038/s41598-021-95309-82045-2322https://doaj.org/article/aab0820c77334dbe82a686505ce70f342021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95309-8https://doaj.org/toc/2045-2322Abstract Apocrine secretion is a recently discovered widespread non-canonical and non-vesicular secretory mechanism whose regulation and purpose is only partly defined. Here, we demonstrate that apocrine secretion in the prepupal salivary glands (SGs) of Drosophila provides the sole source of immune-competent and defense-response proteins to the exuvial fluid that lies between the metamorphosing pupae and its pupal case. Genetic ablation of its delivery from the prepupal SGs to the exuvial fluid decreases the survival of pupae to microbial challenges, and the isolated apocrine secretion has strong antimicrobial effects in “agar-plate” tests. Thus, apocrine secretion provides an essential first line of defense against exogenously born infection and represents a highly specialized cellular mechanism for delivering components of innate immunity at the interface between an organism and its external environment.Denisa Beňová-LiszekováLucia MentelováKlaudia BabišováMilan BeňoTibor PechanBruce A. ChaseRobert FarkašNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Denisa Beňová-Liszeková Lucia Mentelová Klaudia Babišová Milan Beňo Tibor Pechan Bruce A. Chase Robert Farkaš An apocrine mechanism delivers a fully immunocompetent exocrine secretion |
| description |
Abstract Apocrine secretion is a recently discovered widespread non-canonical and non-vesicular secretory mechanism whose regulation and purpose is only partly defined. Here, we demonstrate that apocrine secretion in the prepupal salivary glands (SGs) of Drosophila provides the sole source of immune-competent and defense-response proteins to the exuvial fluid that lies between the metamorphosing pupae and its pupal case. Genetic ablation of its delivery from the prepupal SGs to the exuvial fluid decreases the survival of pupae to microbial challenges, and the isolated apocrine secretion has strong antimicrobial effects in “agar-plate” tests. Thus, apocrine secretion provides an essential first line of defense against exogenously born infection and represents a highly specialized cellular mechanism for delivering components of innate immunity at the interface between an organism and its external environment. |
| format |
article |
| author |
Denisa Beňová-Liszeková Lucia Mentelová Klaudia Babišová Milan Beňo Tibor Pechan Bruce A. Chase Robert Farkaš |
| author_facet |
Denisa Beňová-Liszeková Lucia Mentelová Klaudia Babišová Milan Beňo Tibor Pechan Bruce A. Chase Robert Farkaš |
| author_sort |
Denisa Beňová-Liszeková |
| title |
An apocrine mechanism delivers a fully immunocompetent exocrine secretion |
| title_short |
An apocrine mechanism delivers a fully immunocompetent exocrine secretion |
| title_full |
An apocrine mechanism delivers a fully immunocompetent exocrine secretion |
| title_fullStr |
An apocrine mechanism delivers a fully immunocompetent exocrine secretion |
| title_full_unstemmed |
An apocrine mechanism delivers a fully immunocompetent exocrine secretion |
| title_sort |
apocrine mechanism delivers a fully immunocompetent exocrine secretion |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/aab0820c77334dbe82a686505ce70f34 |
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