Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy

Yoshiyuki Kitaguchi1, Shunji Kusaka1, Tatsuo Yamaguchi2, Toshifumi Mihashi2, Takashi Fujikado11Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan; 2Topcon Research Institute, Itabashi, JapanPurpose: To investigate the structural changes in the photorecep...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tatsuo Yamaguchi, Shunji Kusaka, Yoshiyuki Kitaguchi, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/aab12d3ca542467db01fa6272070405e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aab12d3ca542467db01fa6272070405e
record_format	dspace
spelling	oai:doaj.org-article:aab12d3ca542467db01fa6272070405e2021-12-02T00:05:02ZDetection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy1177-54671177-5483https://doaj.org/article/aab12d3ca542467db01fa6272070405e2011-03-01T00:00:00Zhttp://www.dovepress.com/detection-of-photoreceptor-disruption-by-adaptive-optics-fundus-imagin-a6635https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Yoshiyuki Kitaguchi1, Shunji Kusaka1, Tatsuo Yamaguchi2, Toshifumi Mihashi2, Takashi Fujikado11Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan; 2Topcon Research Institute, Itabashi, JapanPurpose: To investigate the structural changes in the photoreceptors by adaptive optics (AO) fundus imaging and Fourier-domain optical coherence tomography (FD-OCT) in eyes with occult macular dystrophy (OMD).Design: Observational case reports.Methods: Eight eyes of four patients who were diagnosed with OMD were examined. All eyes had a complete ophthalmological examination. Multifocal electroretinograms (mfERGs) were recorded from all eyes. AO and FD-OCT images of foveal photoreceptors were obtained.Results: The best-corrected visual acuity (BCVA) of these eyes ranged from 20/20 to 20/200, and the ocular fundus was normal by conventional ocular examination in all eyes. The amplitudes of the mfERGs were decreased in the foveal area. The inner and outer segment (IS/OS) junction of the photoreceptors in the foveal area was disrupted. The IS/OS junction was intact in one eye with a BCVA of 20/20, and the outer segment layer between the IS/OS junction and retinal pigment epithelium of the FD-OCT images was identified only in the center of the fovea. The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea.Conclusion: Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.Keywords: Photoreceptors, OMD, images, retinal imaging Tatsuo YamaguchiShunji KusakaYoshiyuki Kitaguchiet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 345-351 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Tatsuo Yamaguchi Shunji Kusaka Yoshiyuki Kitaguchi et al Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy
description	Yoshiyuki Kitaguchi1, Shunji Kusaka1, Tatsuo Yamaguchi2, Toshifumi Mihashi2, Takashi Fujikado11Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan; 2Topcon Research Institute, Itabashi, JapanPurpose: To investigate the structural changes in the photoreceptors by adaptive optics (AO) fundus imaging and Fourier-domain optical coherence tomography (FD-OCT) in eyes with occult macular dystrophy (OMD).Design: Observational case reports.Methods: Eight eyes of four patients who were diagnosed with OMD were examined. All eyes had a complete ophthalmological examination. Multifocal electroretinograms (mfERGs) were recorded from all eyes. AO and FD-OCT images of foveal photoreceptors were obtained.Results: The best-corrected visual acuity (BCVA) of these eyes ranged from 20/20 to 20/200, and the ocular fundus was normal by conventional ocular examination in all eyes. The amplitudes of the mfERGs were decreased in the foveal area. The inner and outer segment (IS/OS) junction of the photoreceptors in the foveal area was disrupted. The IS/OS junction was intact in one eye with a BCVA of 20/20, and the outer segment layer between the IS/OS junction and retinal pigment epithelium of the FD-OCT images was identified only in the center of the fovea. The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea.Conclusion: Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.Keywords: Photoreceptors, OMD, images, retinal imaging
format	article
author	Tatsuo Yamaguchi Shunji Kusaka Yoshiyuki Kitaguchi et al
author_facet	Tatsuo Yamaguchi Shunji Kusaka Yoshiyuki Kitaguchi et al
author_sort	Tatsuo Yamaguchi
title	Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy
title_short	Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy
title_full	Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy
title_fullStr	Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy
title_full_unstemmed	Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy
title_sort	detection of photoreceptor disruption by adaptive optics fundus imaging and fourier-domain optical coherence tomography in eyes with occult macular dystrophy
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/aab12d3ca542467db01fa6272070405e
work_keys_str_mv	AT tatsuoyamaguchi detectionofphotoreceptordisruptionbyadaptiveopticsfundusimagingandfourierdomainopticalcoherencetomographyineyeswithoccultmaculardystrophy AT shunjikusaka detectionofphotoreceptordisruptionbyadaptiveopticsfundusimagingandfourierdomainopticalcoherencetomographyineyeswithoccultmaculardystrophy AT yoshiyukikitaguchi detectionofphotoreceptordisruptionbyadaptiveopticsfundusimagingandfourierdomainopticalcoherencetomographyineyeswithoccultmaculardystrophy AT etal detectionofphotoreceptordisruptionbyadaptiveopticsfundusimagingandfourierdomainopticalcoherencetomographyineyeswithoccultmaculardystrophy
_version_	1718403947631214592

Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy

Ejemplares similares