Neural correlates of altered feedback learning in women recovered from anorexia nervosa

Abstract Anorexia nervosa (AN) is associated with exaggerated self-control and altered reward-based decision making, but the underlying neural mechanisms are poorly understood. Consistent with the notion of excessive cognitive control, we recently found increased dorsal anterior cingulate cortex (dA...

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Autores principales:	Franziska Ritschel, Daniel Geisler, Joseph A. King, Fabio Bernardoni, Maria Seidel, Ilka Boehm, Richard Vettermann, Ronald Biemann, Veit Roessner, Michael N. Smolka, Stefan Ehrlich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aab8e99452e846358155db4fae99b113
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spelling	oai:doaj.org-article:aab8e99452e846358155db4fae99b1132021-12-02T15:06:20ZNeural correlates of altered feedback learning in women recovered from anorexia nervosa10.1038/s41598-017-04761-y2045-2322https://doaj.org/article/aab8e99452e846358155db4fae99b1132017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04761-yhttps://doaj.org/toc/2045-2322Abstract Anorexia nervosa (AN) is associated with exaggerated self-control and altered reward-based decision making, but the underlying neural mechanisms are poorly understood. Consistent with the notion of excessive cognitive control, we recently found increased dorsal anterior cingulate cortex (dACC) activation in acutely ill patients (acAN) on lose-shift trials in a probabilistic reversal learning (PRL) task. However, undernutrition may modulate brain function. In attempt to disentangle trait from state factors, the current fMRI study investigated cognitive control in recovered patients (recAN). Thirty-one recAN and 31 healthy controls (HC) completed a PRL task during fMRI. Based on previous findings, we focused on hemodynamic responses during lose-shift behaviour and conducted supplementary functional connectivity analysis. RecAN showed elevated lose-shift behaviour relative to HC. On the neural level, recAN showed normal dACC responses, but increased activation in fronto-parietal control regions. A trend for increased coupling between frontal and parietal regions of interest was also evident in recAN. The current findings in recAN differ from those in our previous study in acAN. While aberrant dACC response to negative feedback may be a correlate of the underweight state in acAN, impaired behavioural adaptation and elevated activation of cognitive control regions in recAN is suggestive of altered neural efficiency.Franziska RitschelDaniel GeislerJoseph A. KingFabio BernardoniMaria SeidelIlka BoehmRichard VettermannRonald BiemannVeit RoessnerMichael N. SmolkaStefan EhrlichNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Franziska Ritschel Daniel Geisler Joseph A. King Fabio Bernardoni Maria Seidel Ilka Boehm Richard Vettermann Ronald Biemann Veit Roessner Michael N. Smolka Stefan Ehrlich Neural correlates of altered feedback learning in women recovered from anorexia nervosa
description	Abstract Anorexia nervosa (AN) is associated with exaggerated self-control and altered reward-based decision making, but the underlying neural mechanisms are poorly understood. Consistent with the notion of excessive cognitive control, we recently found increased dorsal anterior cingulate cortex (dACC) activation in acutely ill patients (acAN) on lose-shift trials in a probabilistic reversal learning (PRL) task. However, undernutrition may modulate brain function. In attempt to disentangle trait from state factors, the current fMRI study investigated cognitive control in recovered patients (recAN). Thirty-one recAN and 31 healthy controls (HC) completed a PRL task during fMRI. Based on previous findings, we focused on hemodynamic responses during lose-shift behaviour and conducted supplementary functional connectivity analysis. RecAN showed elevated lose-shift behaviour relative to HC. On the neural level, recAN showed normal dACC responses, but increased activation in fronto-parietal control regions. A trend for increased coupling between frontal and parietal regions of interest was also evident in recAN. The current findings in recAN differ from those in our previous study in acAN. While aberrant dACC response to negative feedback may be a correlate of the underweight state in acAN, impaired behavioural adaptation and elevated activation of cognitive control regions in recAN is suggestive of altered neural efficiency.
format	article
author	Franziska Ritschel Daniel Geisler Joseph A. King Fabio Bernardoni Maria Seidel Ilka Boehm Richard Vettermann Ronald Biemann Veit Roessner Michael N. Smolka Stefan Ehrlich
author_facet	Franziska Ritschel Daniel Geisler Joseph A. King Fabio Bernardoni Maria Seidel Ilka Boehm Richard Vettermann Ronald Biemann Veit Roessner Michael N. Smolka Stefan Ehrlich
author_sort	Franziska Ritschel
title	Neural correlates of altered feedback learning in women recovered from anorexia nervosa
title_short	Neural correlates of altered feedback learning in women recovered from anorexia nervosa
title_full	Neural correlates of altered feedback learning in women recovered from anorexia nervosa
title_fullStr	Neural correlates of altered feedback learning in women recovered from anorexia nervosa
title_full_unstemmed	Neural correlates of altered feedback learning in women recovered from anorexia nervosa
title_sort	neural correlates of altered feedback learning in women recovered from anorexia nervosa
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/aab8e99452e846358155db4fae99b113
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Neural correlates of altered feedback learning in women recovered from anorexia nervosa

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