Measuring and estimating GFR and treatment effect in ADPKD patients: results and implications of a longitudinal cohort study.
Trials failed to demonstrate protective effects of investigational treatments on glomerular filtration rate (GFR) reduction in Autosomal Dominant Polycystic Kidney Disease (ADPKD). To assess whether above findings were explained by unreliable GFR estimates, in this academic study we compared GFR val...
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2012
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oai:doaj.org-article:aabb85bef2dd4f8f92adf7c506764eec2021-11-18T07:26:30ZMeasuring and estimating GFR and treatment effect in ADPKD patients: results and implications of a longitudinal cohort study.1932-620310.1371/journal.pone.0032533https://doaj.org/article/aabb85bef2dd4f8f92adf7c506764eec2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22393413/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Trials failed to demonstrate protective effects of investigational treatments on glomerular filtration rate (GFR) reduction in Autosomal Dominant Polycystic Kidney Disease (ADPKD). To assess whether above findings were explained by unreliable GFR estimates, in this academic study we compared GFR values centrally measured by iohexol plasma clearance with corresponding values estimated by Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi) and abbreviated Modification of Diet in Renal Disease (aMDRD) formulas in ADPKD patients retrieved from four clinical trials run by a Clinical Research Center and five Nephrology Units in Italy. Measured baseline GFRs and one-year GFR changes averaged 78.6±26.7 and 8.4±10.3 mL/min/1.73 m(2) in 111 and 71 ADPKD patients, respectively. CKD-Epi significantly overestimated and aMDRD underestimated baseline GFRs. Less than half estimates deviated by <10% from measured values. One-year estimated GFR changes did not detect measured changes. Both formulas underestimated GFR changes by 50%. Less than 9% of estimates deviated <10% from measured changes. Extent of deviations even exceeded that of measured one-year GFR changes. In ADPKD, prediction formulas unreliably estimate actual GFR values and fail to detect their changes over time. Direct kidney function measurements by appropriate techniques are needed to adequately evaluate treatment effects in clinics and research.Piero RuggenentiFlavio GaspariAntonio CannataFabiola CarraraClaudia CellaSilvia FerrariNadia StucchiSilvia PrandiniBogdan Ene-IordacheOlimpia DiadeiNorberto PericoPatrizia OndeiAntonio PisaniErasmo BuongiornoPiergiorgio MessaMauro DugoGiuseppe RemuzziGFR-ADPKD Study GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e32533 (2012) |
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Medicine R Science Q Piero Ruggenenti Flavio Gaspari Antonio Cannata Fabiola Carrara Claudia Cella Silvia Ferrari Nadia Stucchi Silvia Prandini Bogdan Ene-Iordache Olimpia Diadei Norberto Perico Patrizia Ondei Antonio Pisani Erasmo Buongiorno Piergiorgio Messa Mauro Dugo Giuseppe Remuzzi GFR-ADPKD Study Group Measuring and estimating GFR and treatment effect in ADPKD patients: results and implications of a longitudinal cohort study. |
| description |
Trials failed to demonstrate protective effects of investigational treatments on glomerular filtration rate (GFR) reduction in Autosomal Dominant Polycystic Kidney Disease (ADPKD). To assess whether above findings were explained by unreliable GFR estimates, in this academic study we compared GFR values centrally measured by iohexol plasma clearance with corresponding values estimated by Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi) and abbreviated Modification of Diet in Renal Disease (aMDRD) formulas in ADPKD patients retrieved from four clinical trials run by a Clinical Research Center and five Nephrology Units in Italy. Measured baseline GFRs and one-year GFR changes averaged 78.6±26.7 and 8.4±10.3 mL/min/1.73 m(2) in 111 and 71 ADPKD patients, respectively. CKD-Epi significantly overestimated and aMDRD underestimated baseline GFRs. Less than half estimates deviated by <10% from measured values. One-year estimated GFR changes did not detect measured changes. Both formulas underestimated GFR changes by 50%. Less than 9% of estimates deviated <10% from measured changes. Extent of deviations even exceeded that of measured one-year GFR changes. In ADPKD, prediction formulas unreliably estimate actual GFR values and fail to detect their changes over time. Direct kidney function measurements by appropriate techniques are needed to adequately evaluate treatment effects in clinics and research. |
| format |
article |
| author |
Piero Ruggenenti Flavio Gaspari Antonio Cannata Fabiola Carrara Claudia Cella Silvia Ferrari Nadia Stucchi Silvia Prandini Bogdan Ene-Iordache Olimpia Diadei Norberto Perico Patrizia Ondei Antonio Pisani Erasmo Buongiorno Piergiorgio Messa Mauro Dugo Giuseppe Remuzzi GFR-ADPKD Study Group |
| author_facet |
Piero Ruggenenti Flavio Gaspari Antonio Cannata Fabiola Carrara Claudia Cella Silvia Ferrari Nadia Stucchi Silvia Prandini Bogdan Ene-Iordache Olimpia Diadei Norberto Perico Patrizia Ondei Antonio Pisani Erasmo Buongiorno Piergiorgio Messa Mauro Dugo Giuseppe Remuzzi GFR-ADPKD Study Group |
| author_sort |
Piero Ruggenenti |
| title |
Measuring and estimating GFR and treatment effect in ADPKD patients: results and implications of a longitudinal cohort study. |
| title_short |
Measuring and estimating GFR and treatment effect in ADPKD patients: results and implications of a longitudinal cohort study. |
| title_full |
Measuring and estimating GFR and treatment effect in ADPKD patients: results and implications of a longitudinal cohort study. |
| title_fullStr |
Measuring and estimating GFR and treatment effect in ADPKD patients: results and implications of a longitudinal cohort study. |
| title_full_unstemmed |
Measuring and estimating GFR and treatment effect in ADPKD patients: results and implications of a longitudinal cohort study. |
| title_sort |
measuring and estimating gfr and treatment effect in adpkd patients: results and implications of a longitudinal cohort study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/aabb85bef2dd4f8f92adf7c506764eec |
| work_keys_str_mv |
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