Specific serotonergic denervation affects tau pathology and cognition without altering senile plaques deposition in APP/PS1 mice.

Specific serotonergic denervation affects tau pathology and cognition without altering senile plaques deposition in APP/PS1 mice.

Senile plaques and neurofibrillary tangles are major neuropathological features of Alzheimer's Disease (AD), however neuronal loss is the alteration that best correlates with cognitive impairment in AD patients. Underlying neurotoxic mechanisms are not completely understood although specific ne...

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Autores principales: Juan Jose Ramos-Rodriguez, Sara Molina-Gil, Raquel Rey-Brea, Esther Berrocoso, Monica Garcia-Alloza
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/aabe188cf7b946d3a9571c46294d97b0
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