Biological Properties and Probiotic Potential of Intestinal Lactobacilli

Data on inefficiency in some cases or temporary positive effect of commercial probiotics led to the development of the concept of autoprobiotic therapy. According to this, the correction of disturbed microbiocenoses is carried out using autostrains of indigenous normal flora (bifidobacteria, lactoba...

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Autores principales:	Ekaterina A. Borovkova, Elena V. Alieva, Tatyana V. Frolova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	intestinal lactobacilli antibiotic sensitivity adhesion antagonism autostrains autoprobiotic therapy Science Q
Acceso en línea:	https://doaj.org/article/aabe2f8186e2460ba214139df36c9e0a
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spelling	oai:doaj.org-article:aabe2f8186e2460ba214139df36c9e0a2021-11-23T06:14:41ZBiological Properties and Probiotic Potential of Intestinal Lactobacilli2541-94202587-959610.29413/ABS.2019-4.1.19https://doaj.org/article/aabe2f8186e2460ba214139df36c9e0a2019-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1989https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Data on inefficiency in some cases or temporary positive effect of commercial probiotics led to the development of the concept of autoprobiotic therapy. According to this, the correction of disturbed microbiocenoses is carried out using autostrains of indigenous normal flora (bifidobacteria, lactobacilli and enterococci). However, publications about effectiveness of autoprobiotic therapy are few and contradictory.The aim of the study was to investigate the biological properties and probiotic potential of intestinal lactobacilli, as well as the effectiveness of autoprobiotic therapy, based on Lactobacillus spp.Methods. Biological properties (antibiotic resistance, hemolytic, adhesive and antagonistic activity) were studied in 159 strains of intestinal lactobacilli. Autoprobiotic therapy with sour-milk ferments based on lactobacilli autostrains was carried out in 78 patients of the of the North Caucasus Federal District (NCFD) hospitals to correct the microbiocenosis of the large intestine due to antibiotic therapy.Results. The indigene strains of the intestinal lactobacilli of patients of NCFD hospitals are characterized by a wide spectrum of antibiotic sensitivity, lack of hemolysin production, medium adhesiveness and a high degree of antagonistic activity. Autoprobiotic therapy using Lactobacillus spp. significantly increases the amount of lactobacilli of the large intestine of patients in hospitals of the North Caucasian Federal District.Conclusion. A high probiotic potential of the indigenous intestinal lactobacilli is identified, which makes it possible to use them as effective autoprobiotics. The effectiveness of autoprobiotics with fermented milk starters with Lactobacillus spp. has been proven to restore the normal amount of intestinal lactobacilli patients after the use of broad-spectrum antibiotics.Ekaterina A. BorovkovaElena V. AlievaTatyana V. FrolovaScientific Сentre for Family Health and Human Reproduction Problemsarticleintestinal lactobacilliantibiotic sensitivityadhesionantagonismautostrainsautoprobiotic therapyScienceQRUActa Biomedica Scientifica, Vol 4, Iss 1, Pp 124-132 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	intestinal lactobacilli antibiotic sensitivity adhesion antagonism autostrains autoprobiotic therapy Science Q
spellingShingle	intestinal lactobacilli antibiotic sensitivity adhesion antagonism autostrains autoprobiotic therapy Science Q Ekaterina A. Borovkova Elena V. Alieva Tatyana V. Frolova Biological Properties and Probiotic Potential of Intestinal Lactobacilli
description	Data on inefficiency in some cases or temporary positive effect of commercial probiotics led to the development of the concept of autoprobiotic therapy. According to this, the correction of disturbed microbiocenoses is carried out using autostrains of indigenous normal flora (bifidobacteria, lactobacilli and enterococci). However, publications about effectiveness of autoprobiotic therapy are few and contradictory.The aim of the study was to investigate the biological properties and probiotic potential of intestinal lactobacilli, as well as the effectiveness of autoprobiotic therapy, based on Lactobacillus spp.Methods. Biological properties (antibiotic resistance, hemolytic, adhesive and antagonistic activity) were studied in 159 strains of intestinal lactobacilli. Autoprobiotic therapy with sour-milk ferments based on lactobacilli autostrains was carried out in 78 patients of the of the North Caucasus Federal District (NCFD) hospitals to correct the microbiocenosis of the large intestine due to antibiotic therapy.Results. The indigene strains of the intestinal lactobacilli of patients of NCFD hospitals are characterized by a wide spectrum of antibiotic sensitivity, lack of hemolysin production, medium adhesiveness and a high degree of antagonistic activity. Autoprobiotic therapy using Lactobacillus spp. significantly increases the amount of lactobacilli of the large intestine of patients in hospitals of the North Caucasian Federal District.Conclusion. A high probiotic potential of the indigenous intestinal lactobacilli is identified, which makes it possible to use them as effective autoprobiotics. The effectiveness of autoprobiotics with fermented milk starters with Lactobacillus spp. has been proven to restore the normal amount of intestinal lactobacilli patients after the use of broad-spectrum antibiotics.
format	article
author	Ekaterina A. Borovkova Elena V. Alieva Tatyana V. Frolova
author_facet	Ekaterina A. Borovkova Elena V. Alieva Tatyana V. Frolova
author_sort	Ekaterina A. Borovkova
title	Biological Properties and Probiotic Potential of Intestinal Lactobacilli
title_short	Biological Properties and Probiotic Potential of Intestinal Lactobacilli
title_full	Biological Properties and Probiotic Potential of Intestinal Lactobacilli
title_fullStr	Biological Properties and Probiotic Potential of Intestinal Lactobacilli
title_full_unstemmed	Biological Properties and Probiotic Potential of Intestinal Lactobacilli
title_sort	biological properties and probiotic potential of intestinal lactobacilli
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/aabe2f8186e2460ba214139df36c9e0a
work_keys_str_mv	AT ekaterinaaborovkova biologicalpropertiesandprobioticpotentialofintestinallactobacilli AT elenavalieva biologicalpropertiesandprobioticpotentialofintestinallactobacilli AT tatyanavfrolova biologicalpropertiesandprobioticpotentialofintestinallactobacilli
_version_	1718416967887486976

Biological Properties and Probiotic Potential of Intestinal Lactobacilli

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