Subcutaneous adipose tissue browning, serum orexin-A, and insulin resistance following aerobic exercise in high-fat diet obesity male wistar rats

Background: Subcutaneous adipose tissue (SAT) relative to the other adipose tissues may have different roles in health and insulin resistance. The purpose of this study was to investigate the effectiveness of aerobic exercise on SAT thermogenesis indices, serum orexin-A (OXA), and insulin resistance...

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Autores principales:	Ebrahim Moslehi, Vazgen Minasian, Heibatollah Sadeghi
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	aerobic exercise insulin resistance obesity orexin a subcutaneous adipose tissue Medicine R
Acceso en línea:	https://doaj.org/article/aabe9498068444399bb0caa9d8fa207b
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spelling	oai:doaj.org-article:aabe9498068444399bb0caa9d8fa207b2021-11-12T10:11:33ZSubcutaneous adipose tissue browning, serum orexin-A, and insulin resistance following aerobic exercise in high-fat diet obesity male wistar rats2008-78022008-821310.4103/ijpvm.IJPVM_110_19https://doaj.org/article/aabe9498068444399bb0caa9d8fa207b2021-01-01T00:00:00Zhttp://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2021;volume=12;issue=1;spage=132;epage=132;aulast=Moslehihttps://doaj.org/toc/2008-7802https://doaj.org/toc/2008-8213Background: Subcutaneous adipose tissue (SAT) relative to the other adipose tissues may have different roles in health and insulin resistance. The purpose of this study was to investigate the effectiveness of aerobic exercise on SAT thermogenesis indices, serum orexin-A (OXA), and insulin resistance in high-fat diet-induced obesity male Wistar rats. Methods: Thirty-two male Wistar rats with an average weight of 180–200 g were randomly assigned into 4 equal groups: normal fat diet (NFD), high-fat diet obesity (HFDO), normal fat diet after high-fat diet obesity (HFDO-NFD), and aerobic exercise group with normal fat diet after high-fat diet obesity (HFDO-AEX). Fasting levels of serum OXA, insulin, FBS, high-density lipoproteins, low-density lipoproteins, cholesterol and gene expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and UCP1 in SAT were evaluated. Samples were taken in the HFDO group after obesity-induced and in other groups 48 h after 8 weeks of aerobic exercise. Results: The results showed that HFD significantly decreased serum levels of OXA, HDL-c and gene expression of PGC1α and UCP1 in SAT. In addition, it caused a significant increase in Lee index, FBS, insulin resistance, and serum lipid profile in comparison with the NFD group (P ≤ 0.001). Aerobic exercise significantly modified the changes caused by HFD to the normal levels (P ≤ 0.001). Conclusions: These data suggest that aerobic exercise caused an improvement in insulin resistance and blood lipid profiles through an increase in the serum level of OXA and alteration in the SAT phenotype from white to brown or beige.Ebrahim MoslehiVazgen MinasianHeibatollah SadeghiWolters Kluwer Medknow Publicationsarticle aerobic exerciseinsulin resistanceobesityorexin asubcutaneous adipose tissue MedicineRENInternational Journal of Preventive Medicine, Vol 12, Iss 1, Pp 132-132 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aerobic exercise insulin resistance obesity orexin a subcutaneous adipose tissue Medicine R
spellingShingle	aerobic exercise insulin resistance obesity orexin a subcutaneous adipose tissue Medicine R Ebrahim Moslehi Vazgen Minasian Heibatollah Sadeghi Subcutaneous adipose tissue browning, serum orexin-A, and insulin resistance following aerobic exercise in high-fat diet obesity male wistar rats
description	Background: Subcutaneous adipose tissue (SAT) relative to the other adipose tissues may have different roles in health and insulin resistance. The purpose of this study was to investigate the effectiveness of aerobic exercise on SAT thermogenesis indices, serum orexin-A (OXA), and insulin resistance in high-fat diet-induced obesity male Wistar rats. Methods: Thirty-two male Wistar rats with an average weight of 180–200 g were randomly assigned into 4 equal groups: normal fat diet (NFD), high-fat diet obesity (HFDO), normal fat diet after high-fat diet obesity (HFDO-NFD), and aerobic exercise group with normal fat diet after high-fat diet obesity (HFDO-AEX). Fasting levels of serum OXA, insulin, FBS, high-density lipoproteins, low-density lipoproteins, cholesterol and gene expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and UCP1 in SAT were evaluated. Samples were taken in the HFDO group after obesity-induced and in other groups 48 h after 8 weeks of aerobic exercise. Results: The results showed that HFD significantly decreased serum levels of OXA, HDL-c and gene expression of PGC1α and UCP1 in SAT. In addition, it caused a significant increase in Lee index, FBS, insulin resistance, and serum lipid profile in comparison with the NFD group (P ≤ 0.001). Aerobic exercise significantly modified the changes caused by HFD to the normal levels (P ≤ 0.001). Conclusions: These data suggest that aerobic exercise caused an improvement in insulin resistance and blood lipid profiles through an increase in the serum level of OXA and alteration in the SAT phenotype from white to brown or beige.
format	article
author	Ebrahim Moslehi Vazgen Minasian Heibatollah Sadeghi
author_facet	Ebrahim Moslehi Vazgen Minasian Heibatollah Sadeghi
author_sort	Ebrahim Moslehi
title	Subcutaneous adipose tissue browning, serum orexin-A, and insulin resistance following aerobic exercise in high-fat diet obesity male wistar rats
title_short	Subcutaneous adipose tissue browning, serum orexin-A, and insulin resistance following aerobic exercise in high-fat diet obesity male wistar rats
title_full	Subcutaneous adipose tissue browning, serum orexin-A, and insulin resistance following aerobic exercise in high-fat diet obesity male wistar rats
title_fullStr	Subcutaneous adipose tissue browning, serum orexin-A, and insulin resistance following aerobic exercise in high-fat diet obesity male wistar rats
title_full_unstemmed	Subcutaneous adipose tissue browning, serum orexin-A, and insulin resistance following aerobic exercise in high-fat diet obesity male wistar rats
title_sort	subcutaneous adipose tissue browning, serum orexin-a, and insulin resistance following aerobic exercise in high-fat diet obesity male wistar rats
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/aabe9498068444399bb0caa9d8fa207b
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Subcutaneous adipose tissue browning, serum orexin-A, and insulin resistance following aerobic exercise in high-fat diet obesity male wistar rats

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