Association of Group B Streptococcus colonization and bovine exposure: a prospective cross-sectional cohort study.

<h4>Background</h4>While Group B Streptococcus (GBS) human colonization and infection has long been suspected as originating from cows, several investigators have suggested that ongoing interspecies GBS transmission is unlikely due to genotyping data demonstrating that human and bovine-d...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shannon D Manning, A Cody Springman, Amber D Million, Nicole R Milton, Sara E McNamara, Patricia A Somsel, Paul Bartlett, H Dele Davies
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aabef1d0590e40988b52b44faca112e1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aabef1d0590e40988b52b44faca112e1
record_format	dspace
spelling	oai:doaj.org-article:aabef1d0590e40988b52b44faca112e12021-11-25T06:26:34ZAssociation of Group B Streptococcus colonization and bovine exposure: a prospective cross-sectional cohort study.1932-620310.1371/journal.pone.0008795https://doaj.org/article/aabef1d0590e40988b52b44faca112e12010-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20098699/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>While Group B Streptococcus (GBS) human colonization and infection has long been suspected as originating from cows, several investigators have suggested that ongoing interspecies GBS transmission is unlikely due to genotyping data demonstrating that human and bovine-derived GBS strains represent mostly distinct populations. The possibility of ongoing transmission between humans and their livestock has not been systematically examined.<h4>Methodology/principal findings</h4>To examine ongoing interspecies transmission, we conducted a prospective cross-sectional cohort study of 68 families and their livestock. Stool specimens were collected from 154 people and 115 livestock; GBS was detected in 19 (12.3%) humans and 2 (1.7%) animals (bovine and sheep). Application of multilocus sequence typing (MLST) identified 8 sequence types (STs or clones), with STs 1 and 23 predominating. There were 11 families in which two members submitted stools and at least one had GBS colonization. In 3 of these families, both members (consisting of couples) were colonized, yielding a co-colonization rate of 27% (95% CI: 7%-61%). Two of these couples had strains with identical MLST, capsule (cps) genotype, susceptibility, and RAPD profiles. One couple co-colonized with ST-1 (cps5) strains also had a bovine colonized with the identical strain type. On multivariate analysis of questionnaire data, cattle exposure was a predictor of GBS colonization, with each unit increase in days of cattle exposure increasing the odds of colonization by 20% (P = 0.02). These results support interspecies transmission with additional evidence for transmission provided by the epidemiological association with cattle exposure.<h4>Conclusions/significance</h4>Although GBS uncommonly colonizes livestock stools, increased frequency of cattle exposure was significantly associated with human colonization and one couple shared the same GBS strains as their bovine suggesting intraspecies transmission. These results set the framework for GBS as a possible zoonotic infection, which has significant public health implications.Shannon D ManningA Cody SpringmanAmber D MillionNicole R MiltonSara E McNamaraPatricia A SomselPaul BartlettH Dele DaviesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 1, p e8795 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shannon D Manning A Cody Springman Amber D Million Nicole R Milton Sara E McNamara Patricia A Somsel Paul Bartlett H Dele Davies Association of Group B Streptococcus colonization and bovine exposure: a prospective cross-sectional cohort study.
description	<h4>Background</h4>While Group B Streptococcus (GBS) human colonization and infection has long been suspected as originating from cows, several investigators have suggested that ongoing interspecies GBS transmission is unlikely due to genotyping data demonstrating that human and bovine-derived GBS strains represent mostly distinct populations. The possibility of ongoing transmission between humans and their livestock has not been systematically examined.<h4>Methodology/principal findings</h4>To examine ongoing interspecies transmission, we conducted a prospective cross-sectional cohort study of 68 families and their livestock. Stool specimens were collected from 154 people and 115 livestock; GBS was detected in 19 (12.3%) humans and 2 (1.7%) animals (bovine and sheep). Application of multilocus sequence typing (MLST) identified 8 sequence types (STs or clones), with STs 1 and 23 predominating. There were 11 families in which two members submitted stools and at least one had GBS colonization. In 3 of these families, both members (consisting of couples) were colonized, yielding a co-colonization rate of 27% (95% CI: 7%-61%). Two of these couples had strains with identical MLST, capsule (cps) genotype, susceptibility, and RAPD profiles. One couple co-colonized with ST-1 (cps5) strains also had a bovine colonized with the identical strain type. On multivariate analysis of questionnaire data, cattle exposure was a predictor of GBS colonization, with each unit increase in days of cattle exposure increasing the odds of colonization by 20% (P = 0.02). These results support interspecies transmission with additional evidence for transmission provided by the epidemiological association with cattle exposure.<h4>Conclusions/significance</h4>Although GBS uncommonly colonizes livestock stools, increased frequency of cattle exposure was significantly associated with human colonization and one couple shared the same GBS strains as their bovine suggesting intraspecies transmission. These results set the framework for GBS as a possible zoonotic infection, which has significant public health implications.
format	article
author	Shannon D Manning A Cody Springman Amber D Million Nicole R Milton Sara E McNamara Patricia A Somsel Paul Bartlett H Dele Davies
author_facet	Shannon D Manning A Cody Springman Amber D Million Nicole R Milton Sara E McNamara Patricia A Somsel Paul Bartlett H Dele Davies
author_sort	Shannon D Manning
title	Association of Group B Streptococcus colonization and bovine exposure: a prospective cross-sectional cohort study.
title_short	Association of Group B Streptococcus colonization and bovine exposure: a prospective cross-sectional cohort study.
title_full	Association of Group B Streptococcus colonization and bovine exposure: a prospective cross-sectional cohort study.
title_fullStr	Association of Group B Streptococcus colonization and bovine exposure: a prospective cross-sectional cohort study.
title_full_unstemmed	Association of Group B Streptococcus colonization and bovine exposure: a prospective cross-sectional cohort study.
title_sort	association of group b streptococcus colonization and bovine exposure: a prospective cross-sectional cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/aabef1d0590e40988b52b44faca112e1
work_keys_str_mv	AT shannondmanning associationofgroupbstreptococcuscolonizationandbovineexposureaprospectivecrosssectionalcohortstudy AT acodyspringman associationofgroupbstreptococcuscolonizationandbovineexposureaprospectivecrosssectionalcohortstudy AT amberdmillion associationofgroupbstreptococcuscolonizationandbovineexposureaprospectivecrosssectionalcohortstudy AT nicolermilton associationofgroupbstreptococcuscolonizationandbovineexposureaprospectivecrosssectionalcohortstudy AT saraemcnamara associationofgroupbstreptococcuscolonizationandbovineexposureaprospectivecrosssectionalcohortstudy AT patriciaasomsel associationofgroupbstreptococcuscolonizationandbovineexposureaprospectivecrosssectionalcohortstudy AT paulbartlett associationofgroupbstreptococcuscolonizationandbovineexposureaprospectivecrosssectionalcohortstudy AT hdeledavies associationofgroupbstreptococcuscolonizationandbovineexposureaprospectivecrosssectionalcohortstudy
_version_	1718413700754309120

Association of Group B Streptococcus colonization and bovine exposure: a prospective cross-sectional cohort study.

Ejemplares similares