Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

Amyloid aggregation of mutant p53 contributes to its loss of tumor suppressor function and oncogenic gain-of-function. Here, the authors use a protein mimetic to abrogate mutant p53 aggregation and rescue p53 function, which inhibits cancer cell proliferation in vitro and halts tumor growth in vivo.

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Autores principales:	L. Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Alam, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Yamanappa Hunashal, Jemil Ahmed, Tatiana Houhou, Shake Karapetyan, Zackary Falls, Ram Samudrala, Renu Pasricha, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
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spelling	oai:doaj.org-article:aabfbc8d47544f739652c54bd2eb3f1f2021-12-02T17:12:23ZProtein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function10.1038/s41467-021-23985-12041-1723https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23985-1https://doaj.org/toc/2041-1723Amyloid aggregation of mutant p53 contributes to its loss of tumor suppressor function and oncogenic gain-of-function. Here, the authors use a protein mimetic to abrogate mutant p53 aggregation and rescue p53 function, which inhibits cancer cell proliferation in vitro and halts tumor growth in vivo.L. PalanikumarLaura KarpauskaiteMohamed Al-SayeghIbrahim ChehadeMaheen AlamSarah HassanDebabrata MaityLiaqat AliMona KalmouniYamanappa HunashalJemil AhmedTatiana HouhouShake KarapetyanZackary FallsRam SamudralaRenu PasrichaGennaro EspositoAhmed J. AfzalAndrew D. HamiltonSunil KumarMazin MagzoubNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q L. Palanikumar Laura Karpauskaite Mohamed Al-Sayegh Ibrahim Chehade Maheen Alam Sarah Hassan Debabrata Maity Liaqat Ali Mona Kalmouni Yamanappa Hunashal Jemil Ahmed Tatiana Houhou Shake Karapetyan Zackary Falls Ram Samudrala Renu Pasricha Gennaro Esposito Ahmed J. Afzal Andrew D. Hamilton Sunil Kumar Mazin Magzoub Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function
description	Amyloid aggregation of mutant p53 contributes to its loss of tumor suppressor function and oncogenic gain-of-function. Here, the authors use a protein mimetic to abrogate mutant p53 aggregation and rescue p53 function, which inhibits cancer cell proliferation in vitro and halts tumor growth in vivo.
format	article
author	L. Palanikumar Laura Karpauskaite Mohamed Al-Sayegh Ibrahim Chehade Maheen Alam Sarah Hassan Debabrata Maity Liaqat Ali Mona Kalmouni Yamanappa Hunashal Jemil Ahmed Tatiana Houhou Shake Karapetyan Zackary Falls Ram Samudrala Renu Pasricha Gennaro Esposito Ahmed J. Afzal Andrew D. Hamilton Sunil Kumar Mazin Magzoub
author_facet	L. Palanikumar Laura Karpauskaite Mohamed Al-Sayegh Ibrahim Chehade Maheen Alam Sarah Hassan Debabrata Maity Liaqat Ali Mona Kalmouni Yamanappa Hunashal Jemil Ahmed Tatiana Houhou Shake Karapetyan Zackary Falls Ram Samudrala Renu Pasricha Gennaro Esposito Ahmed J. Afzal Andrew D. Hamilton Sunil Kumar Mazin Magzoub
author_sort	L. Palanikumar
title	Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function
title_short	Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function
title_full	Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function
title_fullStr	Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function
title_full_unstemmed	Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function
title_sort	protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
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Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

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