The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams

It is becoming increasingly apparent that long-term memory formation relies on a distributed network of brain areas. While the hippocampus has been at the center of attention for decades, it is now clear that other regions, in particular the medial prefrontal cortex (mPFC), are taking an active part...

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Autores principales:	Lucie Dixsaut, Johannes Gräff
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mPFC fear memory connectivity engrams Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/aac4417fc86b486a94bbbb49b314e22a
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id	oai:doaj.org-article:aac4417fc86b486a94bbbb49b314e22a
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spelling	oai:doaj.org-article:aac4417fc86b486a94bbbb49b314e22a2021-11-25T17:53:38ZThe Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams10.3390/ijms2222121131422-00671661-6596https://doaj.org/article/aac4417fc86b486a94bbbb49b314e22a2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12113https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067It is becoming increasingly apparent that long-term memory formation relies on a distributed network of brain areas. While the hippocampus has been at the center of attention for decades, it is now clear that other regions, in particular the medial prefrontal cortex (mPFC), are taking an active part as well. Recent evidence suggests that the mPFC—traditionally implicated in the long-term storage of memories—is already critical for the early phases of memory formation such as encoding. In this review, we summarize these findings, relate them to the functional importance of the mPFC connectivity, and discuss the role of the mPFC during memory consolidation with respect to the different theories of memory storage. Owing to its high functional connectivity to other brain areas subserving memory formation and storage, the mPFC emerges as a central hub across the lifetime of a memory, although much still remains to be discovered.Lucie DixsautJohannes GräffMDPI AGarticlemPFCfear memoryconnectivityengramsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12113, p 12113 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mPFC fear memory connectivity engrams Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	mPFC fear memory connectivity engrams Biology (General) QH301-705.5 Chemistry QD1-999 Lucie Dixsaut Johannes Gräff The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams
description	It is becoming increasingly apparent that long-term memory formation relies on a distributed network of brain areas. While the hippocampus has been at the center of attention for decades, it is now clear that other regions, in particular the medial prefrontal cortex (mPFC), are taking an active part as well. Recent evidence suggests that the mPFC—traditionally implicated in the long-term storage of memories—is already critical for the early phases of memory formation such as encoding. In this review, we summarize these findings, relate them to the functional importance of the mPFC connectivity, and discuss the role of the mPFC during memory consolidation with respect to the different theories of memory storage. Owing to its high functional connectivity to other brain areas subserving memory formation and storage, the mPFC emerges as a central hub across the lifetime of a memory, although much still remains to be discovered.
format	article
author	Lucie Dixsaut Johannes Gräff
author_facet	Lucie Dixsaut Johannes Gräff
author_sort	Lucie Dixsaut
title	The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams
title_short	The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams
title_full	The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams
title_fullStr	The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams
title_full_unstemmed	The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams
title_sort	medial prefrontal cortex and fear memory: dynamics, connectivity, and engrams
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/aac4417fc86b486a94bbbb49b314e22a
work_keys_str_mv	AT luciedixsaut themedialprefrontalcortexandfearmemorydynamicsconnectivityandengrams AT johannesgraff themedialprefrontalcortexandfearmemorydynamicsconnectivityandengrams AT luciedixsaut medialprefrontalcortexandfearmemorydynamicsconnectivityandengrams AT johannesgraff medialprefrontalcortexandfearmemorydynamicsconnectivityandengrams
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The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams

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