Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer

ABSTRACT Microbiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral po...

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Autores principales:	Scott A. Handley, Suzanne Devkota
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	bacteriophage colorectal cancer microbiome virome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/aaca8d2c3eff4b668c04fd24f3de4129
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spelling	oai:doaj.org-article:aaca8d2c3eff4b668c04fd24f3de41292021-11-15T15:55:14ZGoing Viral: a Novel Role for Bacteriophage in Colorectal Cancer10.1128/mBio.02626-182150-7511https://doaj.org/article/aaca8d2c3eff4b668c04fd24f3de41292019-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02626-18https://doaj.org/toc/2150-7511ABSTRACT Microbiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral portion of the microbiome, which have emerged with identifiable disease signatures in other diseases, such as inflammatory bowel diseases. Here, G. D. Hannigan, M. B. Duhaime, M. T. Ruffin, IV, C. C. Koumpouras, and P. D. Schloss (mBio 9:e02248-18, https://doi.org/10.1128/mBio.02248-18) present a study that explores the potential bacteriophage signatures in patients with colorectal cancer (CRC) and the associated changes in bacterial signatures. Sampling from a cross section of 60 patients at different stages of CRC in addition to 30 healthy controls, this study highlights the need for greater exploration into the virome, including the “dark matter” of diverse forms that viruses assume in the gastrointestinal tract.Scott A. HandleySuzanne DevkotaAmerican Society for Microbiologyarticlebacteriophagecolorectal cancermicrobiomeviromeMicrobiologyQR1-502ENmBio, Vol 10, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacteriophage colorectal cancer microbiome virome Microbiology QR1-502
spellingShingle	bacteriophage colorectal cancer microbiome virome Microbiology QR1-502 Scott A. Handley Suzanne Devkota Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer
description	ABSTRACT Microbiome-based signatures of disease have focused primarily on the bacterial component of the microbiome for numerous reasons, including ease of sample preparation and depth of the curated bacterial database. However, even more numerous than bacteria are the bacteriophages of the viral portion of the microbiome, which have emerged with identifiable disease signatures in other diseases, such as inflammatory bowel diseases. Here, G. D. Hannigan, M. B. Duhaime, M. T. Ruffin, IV, C. C. Koumpouras, and P. D. Schloss (mBio 9:e02248-18, https://doi.org/10.1128/mBio.02248-18) present a study that explores the potential bacteriophage signatures in patients with colorectal cancer (CRC) and the associated changes in bacterial signatures. Sampling from a cross section of 60 patients at different stages of CRC in addition to 30 healthy controls, this study highlights the need for greater exploration into the virome, including the “dark matter” of diverse forms that viruses assume in the gastrointestinal tract.
format	article
author	Scott A. Handley Suzanne Devkota
author_facet	Scott A. Handley Suzanne Devkota
author_sort	Scott A. Handley
title	Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer
title_short	Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer
title_full	Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer
title_fullStr	Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer
title_full_unstemmed	Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer
title_sort	going viral: a novel role for bacteriophage in colorectal cancer
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/aaca8d2c3eff4b668c04fd24f3de4129
work_keys_str_mv	AT scottahandley goingviralanovelroleforbacteriophageincolorectalcancer AT suzannedevkota goingviralanovelroleforbacteriophageincolorectalcancer
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Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer

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