Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report

Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report

Background: The patients with coronavirus disease 2019 (COVID-19) associated with severe acute respiratory distress syndrome (ARDS) may require prolonged mechanical ventilation which often results in lung fibrosis, thus worsening the prognosis and increasing fatality rates. A mesenchymal stromal cel...

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Main Authors: Kátia Nunes da Silva, Priscila Carvalho Guedes Pinheiro, André Luiz Nunes Gobatto, Rogério da Hora Passos, Bruno Diaz Paredes, Luciana Souza de Aragão França, Carolina Kymie Vasques Nonaka, Beatriz Barreto-Duarte, Mariana Araújo-Pereira, Rafael Tibúrcio, Fernanda Ferreira Cruz, Gabriele Louise Soares Martins, Bruno B. Andrade, Hugo Caire de Castro-Faria-Neto, Patricia Rieken Macêdo Rocco, Bruno Solano de Freitas Souza
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
COVID-19
ARDS
mesenchymal stromal cells (MSCs)
cell therapy
immunomodulation
fibrosis
Medicine (General)
R5-920
Online Access:https://doaj.org/article/aacbb0f219764d21b36c2ccb79f166fd
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https://doaj.org/article/aacbb0f219764d21b36c2ccb79f166fd

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