SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES

Objective: To assess the vulnerability of atherosclerotic plaque in coronary arteries of individuals dying of ischemic heart disease. Study Design: Cross sectional study. Place and Duration of Study: Histopathology department, Combined Military Hospital Lahore, from Nov 2016 to Nov 2017. Me...

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Autores principales:	Sumaira Bukhsh, Samia Nasreen, Hassan Tariq, Syed Salman Ali, Muhammad Umer, Nadeem Zafar, Hafeez Ud Din
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	atherosclerotic plaque cluster of differentiation 68 cluster of differentiation 105 nuclear factor-kappa-light-chainenhancer of activated b cells Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/aad0ba78b618452aab0e6cdf52056ff2
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spelling	oai:doaj.org-article:aad0ba78b618452aab0e6cdf52056ff22021-11-18T03:08:22ZSUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES0030-96482411-8842https://doaj.org/article/aad0ba78b618452aab0e6cdf52056ff22021-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3621/3570https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To assess the vulnerability of atherosclerotic plaque in coronary arteries of individuals dying of ischemic heart disease. Study Design: Cross sectional study. Place and Duration of Study: Histopathology department, Combined Military Hospital Lahore, from Nov 2016 to Nov 2017. Methodology: A total of 43 cases were taken in the study. The Autopsy specimens from the bodies of people dying suddenly of ischemic heart disease were taken into the study. Tissues showing autolytic changes and patients dying with coronary artery disease after corrective procedure like stenting and bypass were excluded. Results: Out of 43 cases, 35 (81.4%) cases were positive for cluster of differentiation 68 (CD 68), 34 (79%) cases were positive for cluster of differentiation 105 (CD 105) & 36 (83.6) cases were positive for nuclear factor kappa-light-chain-enhancer of activated B cells (NF-Kb). Conclusion: People who had died of ischemic heart disease have more vulnerable plaque in their coronary arteries as compared to the people who had died of non-ischemic cause. Early recognition of the un-ruptured plaque is important for the treatment strategies.Sumaira BukhshSamia NasreenHassan TariqSyed Salman AliMuhammad UmerNadeem ZafarHafeez Ud DinArmy Medical College Rawalpindiarticleatherosclerotic plaquecluster of differentiation 68cluster of differentiation 105nuclear factor-kappa-light-chainenhancer of activated b cellsMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1548-1552 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atherosclerotic plaque cluster of differentiation 68 cluster of differentiation 105 nuclear factor-kappa-light-chainenhancer of activated b cells Medicine R Medicine (General) R5-920
spellingShingle	atherosclerotic plaque cluster of differentiation 68 cluster of differentiation 105 nuclear factor-kappa-light-chainenhancer of activated b cells Medicine R Medicine (General) R5-920 Sumaira Bukhsh Samia Nasreen Hassan Tariq Syed Salman Ali Muhammad Umer Nadeem Zafar Hafeez Ud Din SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES
description	Objective: To assess the vulnerability of atherosclerotic plaque in coronary arteries of individuals dying of ischemic heart disease. Study Design: Cross sectional study. Place and Duration of Study: Histopathology department, Combined Military Hospital Lahore, from Nov 2016 to Nov 2017. Methodology: A total of 43 cases were taken in the study. The Autopsy specimens from the bodies of people dying suddenly of ischemic heart disease were taken into the study. Tissues showing autolytic changes and patients dying with coronary artery disease after corrective procedure like stenting and bypass were excluded. Results: Out of 43 cases, 35 (81.4%) cases were positive for cluster of differentiation 68 (CD 68), 34 (79%) cases were positive for cluster of differentiation 105 (CD 105) & 36 (83.6) cases were positive for nuclear factor kappa-light-chain-enhancer of activated B cells (NF-Kb). Conclusion: People who had died of ischemic heart disease have more vulnerable plaque in their coronary arteries as compared to the people who had died of non-ischemic cause. Early recognition of the un-ruptured plaque is important for the treatment strategies.
format	article
author	Sumaira Bukhsh Samia Nasreen Hassan Tariq Syed Salman Ali Muhammad Umer Nadeem Zafar Hafeez Ud Din
author_facet	Sumaira Bukhsh Samia Nasreen Hassan Tariq Syed Salman Ali Muhammad Umer Nadeem Zafar Hafeez Ud Din
author_sort	Sumaira Bukhsh
title	SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES
title_short	SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES
title_full	SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES
title_fullStr	SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES
title_full_unstemmed	SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES
title_sort	sudden cardiac death: vulnerability of atherosclerotic plaque in coronary arteries
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/aad0ba78b618452aab0e6cdf52056ff2
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SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES

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