Association between mortality and highly antimicrobial-resistant bacteria in intensive care unit-acquired pneumonia

Abstract Data on the relationship between antimicrobial resistance and mortality remain scarce, and this relationship needs to be investigated in intensive care units (ICUs). The aim of this study was to compare the ICU mortality rates between patients with ICU-acquired pneumonia due to highly antim...

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Autores principales: Ines Lakbar, Sophie Medam, Romain Ronflé, Nadim Cassir, Louis Delamarre, Emmanuelle Hammad, Alexandre Lopez, Alain Lepape, Anaïs Machut, Mohamed Boucekine, Laurent Zieleskiewicz, Karine Baumstarck, Anne Savey, Marc Leone, REA RAISIN Study Group
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:aad0eaeaa18749098d5bd6872883b6e72021-12-02T16:28:06ZAssociation between mortality and highly antimicrobial-resistant bacteria in intensive care unit-acquired pneumonia10.1038/s41598-021-95852-42045-2322https://doaj.org/article/aad0eaeaa18749098d5bd6872883b6e72021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95852-4https://doaj.org/toc/2045-2322Abstract Data on the relationship between antimicrobial resistance and mortality remain scarce, and this relationship needs to be investigated in intensive care units (ICUs). The aim of this study was to compare the ICU mortality rates between patients with ICU-acquired pneumonia due to highly antimicrobial-resistant (HAMR) bacteria and those with ICU-acquired pneumonia due to non-HAMR bacteria. We conducted a multicenter, retrospective cohort study using the French National Surveillance Network for Healthcare Associated Infection in ICUs (“REA-Raisin”) database, gathering data from 200 ICUs from January 2007 to December 2016. We assessed all adult patients who were hospitalized for at least 48 h and presented with ICU-acquired pneumonia caused by S. aureus, Enterobacteriaceae, P. aeruginosa, or A. baumannii. The association between pneumonia caused by HAMR bacteria and ICU mortality was analyzed using the whole sample and using a 1:2 matched sample. Among the 18,497 patients with at least one documented case of ICU-acquired pneumonia caused by S. aureus, Enterobacteriaceae, P. aeruginosa, or A. baumannii, 3081 (16.4%) had HAMR bacteria. The HAMR group was associated with increased ICU mortality (40.3% vs. 30%, odds ratio (OR) 95%, CI 1.57 [1.45–1.70], P < 0.001). This association was confirmed in the matched sample (3006 HAMR and 5640 non-HAMR, OR 95%, CI 1.39 [1.27–1.52], P < 0.001) and after adjusting for confounding factors (OR ranged from 1.34 to 1.39, all P < 0.001). Our findings suggest that ICU-acquired pneumonia due to HAMR bacteria is associated with an increased ICU mortality rate, ICU length of stay, and mechanical ventilation duration.Ines LakbarSophie MedamRomain RonfléNadim CassirLouis DelamarreEmmanuelle HammadAlexandre LopezAlain LepapeAnaïs MachutMohamed BoucekineLaurent ZieleskiewiczKarine BaumstarckAnne SaveyMarc LeoneREA RAISIN Study GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ines Lakbar
Sophie Medam
Romain Ronflé
Nadim Cassir
Louis Delamarre
Emmanuelle Hammad
Alexandre Lopez
Alain Lepape
Anaïs Machut
Mohamed Boucekine
Laurent Zieleskiewicz
Karine Baumstarck
Anne Savey
Marc Leone
REA RAISIN Study Group
Association between mortality and highly antimicrobial-resistant bacteria in intensive care unit-acquired pneumonia
description Abstract Data on the relationship between antimicrobial resistance and mortality remain scarce, and this relationship needs to be investigated in intensive care units (ICUs). The aim of this study was to compare the ICU mortality rates between patients with ICU-acquired pneumonia due to highly antimicrobial-resistant (HAMR) bacteria and those with ICU-acquired pneumonia due to non-HAMR bacteria. We conducted a multicenter, retrospective cohort study using the French National Surveillance Network for Healthcare Associated Infection in ICUs (“REA-Raisin”) database, gathering data from 200 ICUs from January 2007 to December 2016. We assessed all adult patients who were hospitalized for at least 48 h and presented with ICU-acquired pneumonia caused by S. aureus, Enterobacteriaceae, P. aeruginosa, or A. baumannii. The association between pneumonia caused by HAMR bacteria and ICU mortality was analyzed using the whole sample and using a 1:2 matched sample. Among the 18,497 patients with at least one documented case of ICU-acquired pneumonia caused by S. aureus, Enterobacteriaceae, P. aeruginosa, or A. baumannii, 3081 (16.4%) had HAMR bacteria. The HAMR group was associated with increased ICU mortality (40.3% vs. 30%, odds ratio (OR) 95%, CI 1.57 [1.45–1.70], P < 0.001). This association was confirmed in the matched sample (3006 HAMR and 5640 non-HAMR, OR 95%, CI 1.39 [1.27–1.52], P < 0.001) and after adjusting for confounding factors (OR ranged from 1.34 to 1.39, all P < 0.001). Our findings suggest that ICU-acquired pneumonia due to HAMR bacteria is associated with an increased ICU mortality rate, ICU length of stay, and mechanical ventilation duration.
format article
author Ines Lakbar
Sophie Medam
Romain Ronflé
Nadim Cassir
Louis Delamarre
Emmanuelle Hammad
Alexandre Lopez
Alain Lepape
Anaïs Machut
Mohamed Boucekine
Laurent Zieleskiewicz
Karine Baumstarck
Anne Savey
Marc Leone
REA RAISIN Study Group
author_facet Ines Lakbar
Sophie Medam
Romain Ronflé
Nadim Cassir
Louis Delamarre
Emmanuelle Hammad
Alexandre Lopez
Alain Lepape
Anaïs Machut
Mohamed Boucekine
Laurent Zieleskiewicz
Karine Baumstarck
Anne Savey
Marc Leone
REA RAISIN Study Group
author_sort Ines Lakbar
title Association between mortality and highly antimicrobial-resistant bacteria in intensive care unit-acquired pneumonia
title_short Association between mortality and highly antimicrobial-resistant bacteria in intensive care unit-acquired pneumonia
title_full Association between mortality and highly antimicrobial-resistant bacteria in intensive care unit-acquired pneumonia
title_fullStr Association between mortality and highly antimicrobial-resistant bacteria in intensive care unit-acquired pneumonia
title_full_unstemmed Association between mortality and highly antimicrobial-resistant bacteria in intensive care unit-acquired pneumonia
title_sort association between mortality and highly antimicrobial-resistant bacteria in intensive care unit-acquired pneumonia
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/aad0eaeaa18749098d5bd6872883b6e7
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