Eosinopenia and neutrophil-to-lymphocyte count ratio as prognostic factors in exacerbation of COPD

Abstract Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPDs) are one of the most important clinical aspects of the disease, and when requiring hospital admission, they significantly contribute to mortality among COPD patients. Our aim was to assess the role of eosinopenia and neutrophil...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tomasz Karauda, Kamil Kornicki, Amer Jarri, Adam Antczak, Joanna Miłkowska-Dymanowska, Wojciech J. Piotrowski, Sebastian Majewski, Paweł Górski, Adam Jerzy Białas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aad0ed4d1f3a4dafad00b58a83cce92a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aad0ed4d1f3a4dafad00b58a83cce92a
record_format	dspace
spelling	oai:doaj.org-article:aad0ed4d1f3a4dafad00b58a83cce92a2021-12-02T13:35:03ZEosinopenia and neutrophil-to-lymphocyte count ratio as prognostic factors in exacerbation of COPD10.1038/s41598-021-84439-82045-2322https://doaj.org/article/aad0ed4d1f3a4dafad00b58a83cce92a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84439-8https://doaj.org/toc/2045-2322Abstract Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPDs) are one of the most important clinical aspects of the disease, and when requiring hospital admission, they significantly contribute to mortality among COPD patients. Our aim was to assess the role of eosinopenia and neutrophil-to-lymphocyte count (NLR) as markers of in-hospital mortality and length of hospitalization (LoH) among patients with ECOPD requiring hospitalization. We included 275 patients. Eosinopenia was associated with in-hospital deaths only when coexisted with lymphocytopenia, with the specificity of 84.4% (95% CI 79.6–88.6%) and the sensitivity of 100% (95% CI 35.9–100%). Also, survivors presented longer LoH (P < 0.0001). NLR ≥ 13.2 predicted in-hospital death with the sensitivity of 100% (95% CI 35.9–100%) and specificity of 92.6% (95% CI 88.8–95.4%), however, comparison of LoH among survivors did not reach statistical significance (P = 0.05). Additionally, when we assessed the presence of coexistence of eosinopenia and lymphocytopenia first, and then apply NLR, sensitivity and specificity in prediction of in-hospital death was 100% (95% CI 35.9–100) and 93.7% (95% CI 90.1–96.3), respectively. Moreover, among survivors, the occurrence of such pattern was associated with significantly longer LoH: 11 (7–14) vs 7 (5–10) days (P = 0.01). The best profile of sensitivity and specificity in the prediction of in-hospital mortality in ECOPD can be obtained by combined analysis of coexistence of eosinopenia and lymphocytopenia with elevated NLR. The occurrence of a such pattern is also associated with significantly longer LoH among survivors.Tomasz KaraudaKamil KornickiAmer JarriAdam AntczakJoanna Miłkowska-DymanowskaWojciech J. PiotrowskiSebastian MajewskiPaweł GórskiAdam Jerzy BiałasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomasz Karauda Kamil Kornicki Amer Jarri Adam Antczak Joanna Miłkowska-Dymanowska Wojciech J. Piotrowski Sebastian Majewski Paweł Górski Adam Jerzy Białas Eosinopenia and neutrophil-to-lymphocyte count ratio as prognostic factors in exacerbation of COPD
description	Abstract Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPDs) are one of the most important clinical aspects of the disease, and when requiring hospital admission, they significantly contribute to mortality among COPD patients. Our aim was to assess the role of eosinopenia and neutrophil-to-lymphocyte count (NLR) as markers of in-hospital mortality and length of hospitalization (LoH) among patients with ECOPD requiring hospitalization. We included 275 patients. Eosinopenia was associated with in-hospital deaths only when coexisted with lymphocytopenia, with the specificity of 84.4% (95% CI 79.6–88.6%) and the sensitivity of 100% (95% CI 35.9–100%). Also, survivors presented longer LoH (P < 0.0001). NLR ≥ 13.2 predicted in-hospital death with the sensitivity of 100% (95% CI 35.9–100%) and specificity of 92.6% (95% CI 88.8–95.4%), however, comparison of LoH among survivors did not reach statistical significance (P = 0.05). Additionally, when we assessed the presence of coexistence of eosinopenia and lymphocytopenia first, and then apply NLR, sensitivity and specificity in prediction of in-hospital death was 100% (95% CI 35.9–100) and 93.7% (95% CI 90.1–96.3), respectively. Moreover, among survivors, the occurrence of such pattern was associated with significantly longer LoH: 11 (7–14) vs 7 (5–10) days (P = 0.01). The best profile of sensitivity and specificity in the prediction of in-hospital mortality in ECOPD can be obtained by combined analysis of coexistence of eosinopenia and lymphocytopenia with elevated NLR. The occurrence of a such pattern is also associated with significantly longer LoH among survivors.
format	article
author	Tomasz Karauda Kamil Kornicki Amer Jarri Adam Antczak Joanna Miłkowska-Dymanowska Wojciech J. Piotrowski Sebastian Majewski Paweł Górski Adam Jerzy Białas
author_facet	Tomasz Karauda Kamil Kornicki Amer Jarri Adam Antczak Joanna Miłkowska-Dymanowska Wojciech J. Piotrowski Sebastian Majewski Paweł Górski Adam Jerzy Białas
author_sort	Tomasz Karauda
title	Eosinopenia and neutrophil-to-lymphocyte count ratio as prognostic factors in exacerbation of COPD
title_short	Eosinopenia and neutrophil-to-lymphocyte count ratio as prognostic factors in exacerbation of COPD
title_full	Eosinopenia and neutrophil-to-lymphocyte count ratio as prognostic factors in exacerbation of COPD
title_fullStr	Eosinopenia and neutrophil-to-lymphocyte count ratio as prognostic factors in exacerbation of COPD
title_full_unstemmed	Eosinopenia and neutrophil-to-lymphocyte count ratio as prognostic factors in exacerbation of COPD
title_sort	eosinopenia and neutrophil-to-lymphocyte count ratio as prognostic factors in exacerbation of copd
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aad0ed4d1f3a4dafad00b58a83cce92a
work_keys_str_mv	AT tomaszkarauda eosinopeniaandneutrophiltolymphocytecountratioasprognosticfactorsinexacerbationofcopd AT kamilkornicki eosinopeniaandneutrophiltolymphocytecountratioasprognosticfactorsinexacerbationofcopd AT amerjarri eosinopeniaandneutrophiltolymphocytecountratioasprognosticfactorsinexacerbationofcopd AT adamantczak eosinopeniaandneutrophiltolymphocytecountratioasprognosticfactorsinexacerbationofcopd AT joannamiłkowskadymanowska eosinopeniaandneutrophiltolymphocytecountratioasprognosticfactorsinexacerbationofcopd AT wojciechjpiotrowski eosinopeniaandneutrophiltolymphocytecountratioasprognosticfactorsinexacerbationofcopd AT sebastianmajewski eosinopeniaandneutrophiltolymphocytecountratioasprognosticfactorsinexacerbationofcopd AT pawełgorski eosinopeniaandneutrophiltolymphocytecountratioasprognosticfactorsinexacerbationofcopd AT adamjerzybiałas eosinopeniaandneutrophiltolymphocytecountratioasprognosticfactorsinexacerbationofcopd
_version_	1718392692053901312

Eosinopenia and neutrophil-to-lymphocyte count ratio as prognostic factors in exacerbation of COPD

Ejemplares similares