Global discovery of lupus genetic risk variant allelic enhancer activity

Thousands of genetic variants have been associated with lupus, but causal variants and mechanisms are unknown. Here, the authors combine a massively parallel reporter assay with genome-wide ChIP experiments to identify risk variants with allelic enhancer activity mediated through transcription facto...

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Autores principales:	Xiaoming Lu, Xiaoting Chen, Carmy Forney, Omer Donmez, Daniel Miller, Sreeja Parameswaran, Ted Hong, Yongbo Huang, Mario Pujato, Tareian Cazares, Emily R. Miraldi, John P. Ray, Carl G. de Boer, John B. Harley, Matthew T. Weirauch, Leah C. Kottyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aad49cc516be41898af7df55bb543c1e
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spelling	oai:doaj.org-article:aad49cc516be41898af7df55bb543c1e2021-12-02T13:15:56ZGlobal discovery of lupus genetic risk variant allelic enhancer activity10.1038/s41467-021-21854-52041-1723https://doaj.org/article/aad49cc516be41898af7df55bb543c1e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21854-5https://doaj.org/toc/2041-1723Thousands of genetic variants have been associated with lupus, but causal variants and mechanisms are unknown. Here, the authors combine a massively parallel reporter assay with genome-wide ChIP experiments to identify risk variants with allelic enhancer activity mediated through transcription factor binding.Xiaoming LuXiaoting ChenCarmy ForneyOmer DonmezDaniel MillerSreeja ParameswaranTed HongYongbo HuangMario PujatoTareian CazaresEmily R. MiraldiJohn P. RayCarl G. de BoerJohn B. HarleyMatthew T. WeirauchLeah C. KottyanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoming Lu Xiaoting Chen Carmy Forney Omer Donmez Daniel Miller Sreeja Parameswaran Ted Hong Yongbo Huang Mario Pujato Tareian Cazares Emily R. Miraldi John P. Ray Carl G. de Boer John B. Harley Matthew T. Weirauch Leah C. Kottyan Global discovery of lupus genetic risk variant allelic enhancer activity
description	Thousands of genetic variants have been associated with lupus, but causal variants and mechanisms are unknown. Here, the authors combine a massively parallel reporter assay with genome-wide ChIP experiments to identify risk variants with allelic enhancer activity mediated through transcription factor binding.
format	article
author	Xiaoming Lu Xiaoting Chen Carmy Forney Omer Donmez Daniel Miller Sreeja Parameswaran Ted Hong Yongbo Huang Mario Pujato Tareian Cazares Emily R. Miraldi John P. Ray Carl G. de Boer John B. Harley Matthew T. Weirauch Leah C. Kottyan
author_facet	Xiaoming Lu Xiaoting Chen Carmy Forney Omer Donmez Daniel Miller Sreeja Parameswaran Ted Hong Yongbo Huang Mario Pujato Tareian Cazares Emily R. Miraldi John P. Ray Carl G. de Boer John B. Harley Matthew T. Weirauch Leah C. Kottyan
author_sort	Xiaoming Lu
title	Global discovery of lupus genetic risk variant allelic enhancer activity
title_short	Global discovery of lupus genetic risk variant allelic enhancer activity
title_full	Global discovery of lupus genetic risk variant allelic enhancer activity
title_fullStr	Global discovery of lupus genetic risk variant allelic enhancer activity
title_full_unstemmed	Global discovery of lupus genetic risk variant allelic enhancer activity
title_sort	global discovery of lupus genetic risk variant allelic enhancer activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aad49cc516be41898af7df55bb543c1e
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Global discovery of lupus genetic risk variant allelic enhancer activity

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