Global discovery of lupus genetic risk variant allelic enhancer activity

Global discovery of lupus genetic risk variant allelic enhancer activity

Thousands of genetic variants have been associated with lupus, but causal variants and mechanisms are unknown. Here, the authors combine a massively parallel reporter assay with genome-wide ChIP experiments to identify risk variants with allelic enhancer activity mediated through transcription facto...

Full description

Saved in:
Bibliographic Details
Main Authors: Xiaoming Lu, Xiaoting Chen, Carmy Forney, Omer Donmez, Daniel Miller, Sreeja Parameswaran, Ted Hong, Yongbo Huang, Mario Pujato, Tareian Cazares, Emily R. Miraldi, John P. Ray, Carl G. de Boer, John B. Harley, Matthew T. Weirauch, Leah C. Kottyan
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/aad49cc516be41898af7df55bb543c1e
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/aad49cc516be41898af7df55bb543c1e

Similar Items