Regulatory T-cells and associated pathways in metastatic renal cell carcinoma (mRCC) patients undergoing DC-vaccination and cytokine-therapy.

Regulatory T-cells and associated pathways in metastatic renal cell carcinoma (mRCC) patients undergoing DC-vaccination and cytokine-therapy.

<h4>Purpose</h4>To evaluate CD4(+)CD25(+)FOXP3(+) T regulatory cells (T(REG)) and associated immune-regulatory pathways in peripheral blood lymphocytes (PBL) of metastatic renal cell carcinoma (mRCC) patients and healthy volunteers. We subsequently investigated the effects of immunothera...

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Main Authors: Adrian Schwarzer, Benita Wolf, Jan L Fisher, Thomas Schwaab, Sven Olek, Udo Baron, Craig R Tomlinson, John D Seigne, Nancy A Crosby, Jiang Gui, Thomas H Hampton, Camilo E Fadul, John A Heaney, Marc S Ernstoff
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/aad50d9d301d4c0fa7552b1ae4b4d3a9
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