Novel candidate genes associated with hippocampal oscillations.

The hippocampus is critical for a wide range of emotional and cognitive behaviors. Here, we performed the first genome-wide search for genes influencing hippocampal oscillations. We measured local field potentials (LFPs) using 64-channel multi-electrode arrays in acute hippocampal slices of 29 BXD r...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rick Jansen, Jaap Timmerman, Maarten Loos, Sabine Spijker, Arjen van Ooyen, Arjen B Brussaard, Huibert D Mansvelder, Neuro-Bsik Mouse Phenomics Consortium, August B Smit, Mathisca de Gunst, Klaus Linkenkaer-Hansen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aad73a10a2394f60aec19bb2d976568a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aad73a10a2394f60aec19bb2d976568a
record_format	dspace
spelling	oai:doaj.org-article:aad73a10a2394f60aec19bb2d976568a2021-11-18T07:35:20ZNovel candidate genes associated with hippocampal oscillations.1932-620310.1371/journal.pone.0026586https://doaj.org/article/aad73a10a2394f60aec19bb2d976568a2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22066001/?tool=EBIhttps://doaj.org/toc/1932-6203The hippocampus is critical for a wide range of emotional and cognitive behaviors. Here, we performed the first genome-wide search for genes influencing hippocampal oscillations. We measured local field potentials (LFPs) using 64-channel multi-electrode arrays in acute hippocampal slices of 29 BXD recombinant inbred mouse strains. Spontaneous activity and carbachol-induced fast network oscillations were analyzed with spectral and cross-correlation methods and the resulting traits were used for mapping quantitative trait loci (QTLs), i.e., regions on the genome that may influence hippocampal function. Using genome-wide hippocampal gene expression data, we narrowed the QTLs to eight candidate genes, including Plcb1, a phospholipase that is known to influence hippocampal oscillations. We also identified two genes coding for calcium channels, Cacna1b and Cacna1e, which mediate presynaptic transmitter release and have not been shown to regulate hippocampal network activity previously. Furthermore, we showed that the amplitude of the hippocampal oscillations is genetically correlated with hippocampal volume and several measures of novel environment exploration.Rick JansenJaap TimmermanMaarten LoosSabine SpijkerArjen van OoyenArjen B BrussaardHuibert D MansvelderNeuro-Bsik Mouse Phenomics ConsortiumAugust B SmitMathisca de GunstKlaus Linkenkaer-HansenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 10, p e26586 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rick Jansen Jaap Timmerman Maarten Loos Sabine Spijker Arjen van Ooyen Arjen B Brussaard Huibert D Mansvelder Neuro-Bsik Mouse Phenomics Consortium August B Smit Mathisca de Gunst Klaus Linkenkaer-Hansen Novel candidate genes associated with hippocampal oscillations.
description	The hippocampus is critical for a wide range of emotional and cognitive behaviors. Here, we performed the first genome-wide search for genes influencing hippocampal oscillations. We measured local field potentials (LFPs) using 64-channel multi-electrode arrays in acute hippocampal slices of 29 BXD recombinant inbred mouse strains. Spontaneous activity and carbachol-induced fast network oscillations were analyzed with spectral and cross-correlation methods and the resulting traits were used for mapping quantitative trait loci (QTLs), i.e., regions on the genome that may influence hippocampal function. Using genome-wide hippocampal gene expression data, we narrowed the QTLs to eight candidate genes, including Plcb1, a phospholipase that is known to influence hippocampal oscillations. We also identified two genes coding for calcium channels, Cacna1b and Cacna1e, which mediate presynaptic transmitter release and have not been shown to regulate hippocampal network activity previously. Furthermore, we showed that the amplitude of the hippocampal oscillations is genetically correlated with hippocampal volume and several measures of novel environment exploration.
format	article
author	Rick Jansen Jaap Timmerman Maarten Loos Sabine Spijker Arjen van Ooyen Arjen B Brussaard Huibert D Mansvelder Neuro-Bsik Mouse Phenomics Consortium August B Smit Mathisca de Gunst Klaus Linkenkaer-Hansen
author_facet	Rick Jansen Jaap Timmerman Maarten Loos Sabine Spijker Arjen van Ooyen Arjen B Brussaard Huibert D Mansvelder Neuro-Bsik Mouse Phenomics Consortium August B Smit Mathisca de Gunst Klaus Linkenkaer-Hansen
author_sort	Rick Jansen
title	Novel candidate genes associated with hippocampal oscillations.
title_short	Novel candidate genes associated with hippocampal oscillations.
title_full	Novel candidate genes associated with hippocampal oscillations.
title_fullStr	Novel candidate genes associated with hippocampal oscillations.
title_full_unstemmed	Novel candidate genes associated with hippocampal oscillations.
title_sort	novel candidate genes associated with hippocampal oscillations.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/aad73a10a2394f60aec19bb2d976568a
work_keys_str_mv	AT rickjansen novelcandidategenesassociatedwithhippocampaloscillations AT jaaptimmerman novelcandidategenesassociatedwithhippocampaloscillations AT maartenloos novelcandidategenesassociatedwithhippocampaloscillations AT sabinespijker novelcandidategenesassociatedwithhippocampaloscillations AT arjenvanooyen novelcandidategenesassociatedwithhippocampaloscillations AT arjenbbrussaard novelcandidategenesassociatedwithhippocampaloscillations AT huibertdmansvelder novelcandidategenesassociatedwithhippocampaloscillations AT neurobsikmousephenomicsconsortium novelcandidategenesassociatedwithhippocampaloscillations AT augustbsmit novelcandidategenesassociatedwithhippocampaloscillations AT mathiscadegunst novelcandidategenesassociatedwithhippocampaloscillations AT klauslinkenkaerhansen novelcandidategenesassociatedwithhippocampaloscillations
_version_	1718423241206267904

Novel candidate genes associated with hippocampal oscillations.

Ejemplares similares