Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury

Stem cell-derived macrophages could treat liver fibrosis Macrophages, a type of white blood cell, when derived from embryonic stem cells in the laboratory reduce fibrosis in chronic liver disease. Lesley Forrester and colleagues from the University of Edinburgh found murine embryonic stem-cell-deriv...

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Autores principales:	Sharmin S. Haideri, Alison C. McKinnon, A. Helen Taylor, Phoebe Kirkwood, Philip J. Starkey Lewis, Eoghan O’Duibhir, Bertrand Vernay, Stuart Forbes, Lesley M. Forrester
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/aad90fc453e148b789e551de85f93a2f
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spelling	oai:doaj.org-article:aad90fc453e148b789e551de85f93a2f2021-12-02T13:41:45ZInjection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury10.1038/s41536-017-0017-02057-3995https://doaj.org/article/aad90fc453e148b789e551de85f93a2f2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0017-0https://doaj.org/toc/2057-3995Stem cell-derived macrophages could treat liver fibrosis Macrophages, a type of white blood cell, when derived from embryonic stem cells in the laboratory reduce fibrosis in chronic liver disease. Lesley Forrester and colleagues from the University of Edinburgh found murine embryonic stem-cell-derived macrophages (ESDM) were morphologically similar to bone marrow-derived macrophages (BMDM), previously found to reduce fibrosis and improve liver function in mice with induced liver injury. Using a novel technique, the team found ESDM engulfed fewer particles at a slower rate than BMDM, indicating ESDM were less inflammatory. A higher dose of ESDM was required to have the same effect of BMDM to help liver fibrosis regression. However, they were more efficient in repopulating mouse livers depleted of liver-specific macrophages and also significantly improved liver function, indicating ESDM were similar to resident macrophages in the liver and had therapeutic potential.Sharmin S. HaideriAlison C. McKinnonA. Helen TaylorPhoebe KirkwoodPhilip J. Starkey LewisEoghan O’DuibhirBertrand VernayStuart ForbesLesley M. ForresterNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Sharmin S. Haideri Alison C. McKinnon A. Helen Taylor Phoebe Kirkwood Philip J. Starkey Lewis Eoghan O’Duibhir Bertrand Vernay Stuart Forbes Lesley M. Forrester Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury
description	Stem cell-derived macrophages could treat liver fibrosis Macrophages, a type of white blood cell, when derived from embryonic stem cells in the laboratory reduce fibrosis in chronic liver disease. Lesley Forrester and colleagues from the University of Edinburgh found murine embryonic stem-cell-derived macrophages (ESDM) were morphologically similar to bone marrow-derived macrophages (BMDM), previously found to reduce fibrosis and improve liver function in mice with induced liver injury. Using a novel technique, the team found ESDM engulfed fewer particles at a slower rate than BMDM, indicating ESDM were less inflammatory. A higher dose of ESDM was required to have the same effect of BMDM to help liver fibrosis regression. However, they were more efficient in repopulating mouse livers depleted of liver-specific macrophages and also significantly improved liver function, indicating ESDM were similar to resident macrophages in the liver and had therapeutic potential.
format	article
author	Sharmin S. Haideri Alison C. McKinnon A. Helen Taylor Phoebe Kirkwood Philip J. Starkey Lewis Eoghan O’Duibhir Bertrand Vernay Stuart Forbes Lesley M. Forrester
author_facet	Sharmin S. Haideri Alison C. McKinnon A. Helen Taylor Phoebe Kirkwood Philip J. Starkey Lewis Eoghan O’Duibhir Bertrand Vernay Stuart Forbes Lesley M. Forrester
author_sort	Sharmin S. Haideri
title	Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury
title_short	Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury
title_full	Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury
title_fullStr	Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury
title_full_unstemmed	Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury
title_sort	injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/aad90fc453e148b789e551de85f93a2f
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Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury

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