Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor

Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor

Monitoring DNA binding and single-base mismatches accurately in real time is difficult, especially for miniaturized devices. Here the authors report a graphene field-effect transistor array capable of reliably measuring DNA hybridization kinetics and affinity at the picomolar level.

Guardado en:
Detalles Bibliográficos
Autores principales: Shicai Xu, Jian Zhan, Baoyuan Man, Shouzhen Jiang, Weiwei Yue, Shoubao Gao, Chengang Guo, Hanping Liu, Zhenhua Li, Jihua Wang, Yaoqi Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/aae2dd43934f415a82bf00c21e1a2521
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:aae2dd43934f415a82bf00c21e1a2521
record_format dspace
spelling oai:doaj.org-article:aae2dd43934f415a82bf00c21e1a25212021-12-02T17:06:28ZReal-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor10.1038/ncomms149022041-1723https://doaj.org/article/aae2dd43934f415a82bf00c21e1a25212017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14902https://doaj.org/toc/2041-1723Monitoring DNA binding and single-base mismatches accurately in real time is difficult, especially for miniaturized devices. Here the authors report a graphene field-effect transistor array capable of reliably measuring DNA hybridization kinetics and affinity at the picomolar level.Shicai XuJian ZhanBaoyuan ManShouzhen JiangWeiwei YueShoubao GaoChengang GuoHanping LiuZhenhua LiJihua WangYaoqi ZhouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shicai Xu
Jian Zhan
Baoyuan Man
Shouzhen Jiang
Weiwei Yue
Shoubao Gao
Chengang Guo
Hanping Liu
Zhenhua Li
Jihua Wang
Yaoqi Zhou
Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor
description Monitoring DNA binding and single-base mismatches accurately in real time is difficult, especially for miniaturized devices. Here the authors report a graphene field-effect transistor array capable of reliably measuring DNA hybridization kinetics and affinity at the picomolar level.
format article
author Shicai Xu
Jian Zhan
Baoyuan Man
Shouzhen Jiang
Weiwei Yue
Shoubao Gao
Chengang Guo
Hanping Liu
Zhenhua Li
Jihua Wang
Yaoqi Zhou
author_facet Shicai Xu
Jian Zhan
Baoyuan Man
Shouzhen Jiang
Weiwei Yue
Shoubao Gao
Chengang Guo
Hanping Liu
Zhenhua Li
Jihua Wang
Yaoqi Zhou
author_sort Shicai Xu
title Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor
title_short Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor
title_full Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor
title_fullStr Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor
title_full_unstemmed Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor
title_sort real-time reliable determination of binding kinetics of dna hybridization using a multi-channel graphene biosensor
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/aae2dd43934f415a82bf00c21e1a2521
work_keys_str_mv AT shicaixu realtimereliabledeterminationofbindingkineticsofdnahybridizationusingamultichannelgraphenebiosensor
AT jianzhan realtimereliabledeterminationofbindingkineticsofdnahybridizationusingamultichannelgraphenebiosensor
AT baoyuanman realtimereliabledeterminationofbindingkineticsofdnahybridizationusingamultichannelgraphenebiosensor
AT shouzhenjiang realtimereliabledeterminationofbindingkineticsofdnahybridizationusingamultichannelgraphenebiosensor
AT weiweiyue realtimereliabledeterminationofbindingkineticsofdnahybridizationusingamultichannelgraphenebiosensor
AT shoubaogao realtimereliabledeterminationofbindingkineticsofdnahybridizationusingamultichannelgraphenebiosensor
AT chengangguo realtimereliabledeterminationofbindingkineticsofdnahybridizationusingamultichannelgraphenebiosensor
AT hanpingliu realtimereliabledeterminationofbindingkineticsofdnahybridizationusingamultichannelgraphenebiosensor
AT zhenhuali realtimereliabledeterminationofbindingkineticsofdnahybridizationusingamultichannelgraphenebiosensor
AT jihuawang realtimereliabledeterminationofbindingkineticsofdnahybridizationusingamultichannelgraphenebiosensor
AT yaoqizhou realtimereliabledeterminationofbindingkineticsofdnahybridizationusingamultichannelgraphenebiosensor
_version_ 1718381631134236672

Ejemplares similares