Mpath maps multi-branching single-cell trajectories revealing progenitor cell progression during development

The tools for constructing cell lineages from single cell data are limited. Here, the authors present Mpath: an algorithm to derive multi-branching trajectories using neighbourhood-based cell state transitions, and use this to predict developmental trajectories in dendritic and muscle cells.

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Detalles Bibliográficos
Autores principales: Jinmiao Chen, Andreas Schlitzer, Svetoslav Chakarov, Florent Ginhoux, Michael Poidinger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/aae42a9a97c4479cb291f76d450c86e4
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Descripción
Sumario:The tools for constructing cell lineages from single cell data are limited. Here, the authors present Mpath: an algorithm to derive multi-branching trajectories using neighbourhood-based cell state transitions, and use this to predict developmental trajectories in dendritic and muscle cells.